AAA

AAA is an antagonist of G protein-coupled receptor 75 (GPR75). It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 µM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-kappaB, and Akt in, and cell migration of, PC3 cells. In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension when administered prior to induction or after establishment of hypertension.Formal Name: (20-hydroxyicosa-6Z,15Z-dienoyl)aspartate, disodium salt. Molecular Formula: C24H39NO6 . 2Na. Formula Weight: 483.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: slightly soluble, PBS (pH 7.2): 1 mg/ml. SMILES: OCCCC/C=C\CCCCCCC/C=C\CCCCC(NC(C([O-])=O)CC([O-])=O)=O.[Na+].[Na+]. InChi Code: InChI=1S/C24H41NO6.2Na/c26-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-22(27)25-21(24(30)31)20-23(28)29,,/h8-11,21,26H,1-7,12-20H2,(H,25,27)(H,28,29)(H,30,31),,/q,2*+1/p-2/b10-8-,11-9-,,. InChi Key: JGVHCBALWPPEGB-UJJOPKMPSA-L.