A2ti-1

A2ti-1 is an inhibitor of the protein-protein interaction between annexin A2 and S100A10 (IC50 = 24 µM in a cell-free assay). It prevents human papillomavirus 16 (HPV16) infection in HeLa cells when used at concentrations ranging from 25 to 100 µM. A2ti-1 (2 and 10 µM) enhances cytotoxicity induced by doxorubicin (Cay-15007) in Hs 578T triple-negative breast cancer (TNBC) cells. It disrupts circadian regulation of intracellular calcium oscillations in primary mouse suprachiasmatic nucleus astrocytes and neurons when used at a concentration of 80 µM. InChI: InChI=1S/C20H22N4O2S/c1-3-15-9-5-6-10-16(15)24-19(22-23-20(24)27-13-18(21)25)12-26-17-11-7-4-8-14(17)2/h4-11H,3,12-13H2,1-2H3,(H2,21,25) InChIKey: KNQGIFUBCFRGDB-UHFFFAOYSA-N SMILES: CCC1=C(C=CC=C1)N2C(COC(C=CC=C3)=C3C)=NN=C2SCC(N)=O