A2764 (hydrochloride)

A2764 is an inhibitor of the two-pore domain potassium channel K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor). It is selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM. A2764 (100 µM) inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons.Formal Name: 2-[(5-chloro-8-quinolinyl)oxy]-N,N-diethyl-ethanamine, dihydrochloride. CAS Number: 861038-72-4. Molecular Formula: C15H19ClN2O . 2HCl. Formula Weight: 351.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Ethanol: Slightly soluble, PBS (pH 7.2): 5 mg/ml. lambdamax: 244 nm. SMILES: CCN(CC)CCOC1=CC=C(Cl)C2=C1N=CC=C2.Cl.Cl. InChi Code: InChI=1S/C15H19ClN2O.2ClH/c1-3-18(4-2)10-11-19-14-8-7-13(16)12-6-5-9-17-15(12)14,,/h5-9H,3-4,10-11H2,1-2H3,2*1H. InChi Key: ZVRDPULCSHGKBD-UHFFFAOYSA-N.