A-740003
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Larger quantity required? Request bulk
Description: A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50:... more
Product information "A-740003"
Description: A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuroblastoma tumor growth in mice. Target: P2X Receptor. Smiles: COc1ccc(CC(=O)NC(N\C(Nc2cccc3ncccc23)=N\C#N)C(C)(C)C)cc1OC. References: Kim, J., Ryu, H., & Kang, T. (2011). P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-alpha-mediated pathway in the rat hippocampus following status epilepticus. Journal Of Neuroinflammation, 8(1), 62. doi: 10.1186/1742-2094-8-62
| Keywords: | A 740003 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3690 |
Properties
| Application: | P2RX7 antagonist |
| MW: | 474.55 D |
| Formula: | C26H30N6O3 |
Database Information
| CAS : | 861393-28-4| Matching products |
| KEGG ID : | K05220 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301 |
| P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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