A-1596586

A-1596586 is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) bearing the F508 deletion (F508del) mutation. It increases CFTR levels in CFBE41o- bronchial epithelial cells expressing F508del-CFTR fused to HRP (EC50 = 0.13 µM) and the transepithelial current in primary human bronchial epithelial cells isolated from a patient with cystic fibrosis with the F508del-CFTR mutation (EC50 = 0.028 µM).Formal Name: 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-yl]-cyclopropanecarboxamide. CAS Number: 1918142-34-3. Molecular Formula: C29H27F2NO7. Formula Weight: 539.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1(CC1)C2=CC(OC(F)(F)O3)=C3C=C2)N[C@H](C[C@H](C(C=C4)=CC(OC)=C4OC)OC5=C6)C5=CC=C6OC. InChi Code: InChI=1S/C29H27F2NO7/c1-34-18-6-7-19-20(15-23(37-24(19)14-18)16-4-8-21(35-2)25(12-16)36-3)32-27(33)28(10-11-28)17-5-9-22-26(13-17)39-29(30,31)38-22/h4-9,12-14,20,23H,10-11,15H2,1-3H3,(H,32,33)/t20-,23-/m1/s1. InChi Key: KDOQEEMQPHIANX-NFBKMPQASA-N.