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Immunosuppressant-1
Item number: TGM-T79791-50mg
Description: Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node cells through caspase-3 and PARP activation [1]. Target: Apoptosis
| CAS | 1224571-03-2 |
| MW: | 322.15 D |
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alphavbeta1 integrin-IN-2
Item number: TGM-T79792-50mg
Description: alphavbeta1 integrin-IN-2 (compound 32) is a potent inhibitor of alphanubeta1 and alpha5beta1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. This compound also inhibits other integrins with IC50 values of 380 nM (alphanubeta3), 280 nM (alphanubeta5), 230 nM (alphanubeta6), and 87...
| CAS | 2234874-68-9 |
| MW: | 506.64 D |
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CRF1 receptor antagonist-1
Item number: TGM-T79793-50mg
Description: CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1]. Target: CFTR
| CAS | 2635364-30-4 |
| MW: | 499.04 D |
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TNIK&MAP4K4-IN-1
Item number: TGM-T79794-50mg
Description: TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor of TNIK and MAP4K4/HGK, with IC50 values of 1.29 nM and <10 nM, respectively, in human hepatic stellate cell LX-2, and is applicable in cancer and fibrosis inhibition [1]. Target: Others
| CAS | 2478592-86-6 |
| MW: | 446.47 D |
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USP1-IN-5
Item number: TGM-T79795-50mg
Description: USP1-IN-5 (compound 10) is a potent inhibitor of USP1, with an IC50 of less than 50 nM, and of MDA-MB-436 cells, exhibiting an IC50 of less than 50 nM [1]. Target: Others
| CAS | 2925547-94-8 |
| MW: | 532.52 D |
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USP1-IN-6
Item number: TGM-T79796-50mg
Description: USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM. Additionally, it demonstrates inhibitory activity against MDA-MB-436 cells with a comparable IC50. [1]. Target: Others
| CAS | 2925547-95-9 |
| MW: | 560.57 D |
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PHD-IN-1
Item number: TGM-T79797-50mg
Description: PHD-IN-1 (compound 80) is a potent PHD2 inhibitor with an IC50 value of =5 nM and demonstrates EC50 values of 2.5 µM in EPO Elisa assays in both Caco2-HIF1a-HiBiT-clone-1 and Hep3B cell lines [1]. Target: HIF/HIF Prolyl-Hydroxylase
| CAS | 2924182-31-8 |
| MW: | 441.49 D |
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PHD-IN-2
Item number: TGM-T79798-50mg
Description: PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of less than 2.5 µM. It is applicable for research purposes across various medical fields, including cardiovascular, metabolic, hematological,...
| CAS | 2924182-42-1 |
| MW: | 501.54 D |
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pan-KRAS-IN-4
Item number: TGM-T79799-50mg
Description: Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1]. Target: Ras
| CAS | 2885961-55-5 |
| MW: | 636.69 D |
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pan-KRAS-IN-2
Item number: TGM-T79800-50mg
Description: Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of =10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 µM, for the KRAS G13D mutant [1]. Target: Ras....
| CAS | 2882825-14-9 |
| MW: | 584.66 D |
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5-HT2C agonist-3
Item number: TGM-T79802-50mg
Description: 5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced hyperactivity [1]. Target: 5-HT Receptor
| CAS | 2104810-18-4 |
| MW: | 351.84 D |
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5-HT2C agonist-3 free base
Item number: TGM-T79803-50mg
Description: 5-HT2C agonist-3 ((+)-19) free base is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM) that exhibits antipsychotic drug-like activity and inhibits Amphetamine-induced hyperactivity [1]. Target: 5-HT Receptor
| CAS | 2104810-17-3 |
| MW: | 315.38 D |
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