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PROTAC PTPN2 degrader-2 TFA
Item number: TGM-T79161-50mg
Description: PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2) degrader with potential applications in cancer and metabolic disease research [1]. Target: Phosphatase
| CAS | 2912307-39-0 |
| MW: | 1111.55 D |
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SOS1/KRAS-IN-1
Item number: TGM-T79162-100mg
Description: SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1]. Target: Ras
| CAS | 2836330-34-6 |
| MW: | 457.49 D |
From 1,867.00€
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RET-IN-24
Item number: TGM-T79163-100mg
Description: RET-IN-24 (Compound 26) is a selective RET tyrosine kinase inhibitor with demonstrated antitumor activity [1]. Target: Others
| CAS | 2583767-68-2 |
| MW: | 516.55 D |
From 1,298.00€
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USP7-IN-12
Item number: TGM-T79164-50mg
Description: USP7-IN-12 (compound 1) is a potent, orally active Usp7 inhibitor with an IC50 of 3.67 nM, demonstrating antiproliferative activity [1]. Target: Others
| CAS | 2763698-01-5 |
| MW: | 551.07 D |
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DNA-PK-IN-10
Item number: TGM-T79165-50mg
Description: DNA-PK-IN-10 is a DNA-PK inhibitor used in breast cancer and non-small cell lung cancer research [1]. Target: DNA-PK
| CAS | 2919315-89-0 |
| MW: | 444.53 D |
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KRAS G12C inhibitor 60
Item number: TGM-T79166-50mg
Description: KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreatic cancers [1]. Target: Ras
| MW: | 627.61 D |
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CBP-IN-1
Item number: TGM-T79168-100mg
Description: CBP-IN-1 (compound 12) is a potent CBP inhibitor with an IC50 of 1.5 nM, additionally suppressing CBP BRET and BRD4(1) with IC50 values of 690 nM and 3100 nM, respectively [1]. Target: Epigenetic Reader Domain
| CAS | 1936431-44-5 |
| MW: | 509.59 D |
From 1,298.00€
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CDK7-IN-22
Item number: TGM-T79169-100mg
Description: CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor with demonstrated antitumor activity and specificity for CDK7 [1]. Target: CDK
| CAS | 2173190-60-6 |
| MW: | 430.47 D |
From 1,725.00€
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Immuno modulator-1
Item number: TGM-T79170-50mg
Description: Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFalpha and IL-2 in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 nM and 26 nM, respectively, and exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 µM [1]. Target:...
| CAS | 2757469-20-6 |
| MW: | 582.62 D |
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Bcl-2-IN-11
Item number: TGM-T79171-50mg
Description: Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor with an IC50 of 0.9 nM and minimal inhibition against Bcl-xl (IC50 > 1000 nM). It is used in cancer research related to Bcl-2 family protein overexpression, particularly in hematologic malignancies like acute lymphoid leukemia,...
| CAS | 2760536-88-5 |
| MW: | 902.43 D |
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PF-06655075
Item number: TGM-T79172-50mg
Description: PF-06655075 is a novel, non-brain-penetrant oxytocin receptor agonist that demonstrates enhanced selectivity for the oxytocin receptor and substantially improved pharmacokinetic stability. This compound serves as a tool to further investigate the function of peripheral oxytocin in behavioral responses...
| MW: | 1644.05 D |
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PF-06478939
Item number: TGM-T79173-50mg
Description: PF-06478939 is a peptide that functions as an agonist at the oxytocin (OT) receptor and vasopressin receptor without crossing the blood-brain barrier. It exhibits EC50 values of 0.01 nM at the OT receptor and 0.078 nM at the vasopressin receptor [1]. Target: Oxytocin Receptor
| MW: | 1684.11 D |
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