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PCSK9-IN-14
Item number: TGM-T79030-50mg
Description: PCSK9-IN-14, also known as compound Ia-8, is a potent inhibitor of PCSK9 [1]. Target: Others
| CAS | 2913198-84-0 |
| MW: | 392.26 D |
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ATR-IN-21
Item number: TGM-T79031-50mg
Description: ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1]. Target: ATM/ATR
| CAS | 2905312-17-4 |
| MW: | 417.51 D |
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Enpp-1-IN-17
Item number: TGM-T79032-100mg
Description: Enpp-1-IN-17 (example 274) is a potent inhibitor of ENPP1, with inhibition constants (Ki values) ranging from 100 nM to 1 µM for cGAMP hydrolysis and greater than 1 µM for ATP hydrolysis, demonstrating a selectivity ratio of over 6.4 favoring cGAMP hydrolysis inhibition [1]. Target: Others
| CAS | 2289736-54-3 |
| MW: | 328.41 D |
From 1,440.00€
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ATR-IN-22
Item number: TGM-T79033-50mg
Description: ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 µM and demonstrates anti-tumor activity in colon cancer [1]. Target: ATM/ATR
| CAS | 2905312-07-2 |
| MW: | 445.56 D |
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GXF-111
Item number: TGM-T79034-50mg
Description: GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high binding affinities to both BRD3 BD1 and BRD3 BD2, with K i values of 11.97 nM and 2.35 nM, respectively. This compound is utilized in cancer...
| MW: | 728.28 D |
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PRMT5-IN-28
Item number: TGM-T79035-50mg
Description: PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is involved in gene transcription, mRNA splicing, DNA repair, protein localization, cell fate determination, and signal transduction. Dysregulated PRMT5 activity contributes to oncogenesis...
| CAS | 2242753-66-6 |
| MW: | 406.82 D |
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Mcl-1 inhibitor 13
Item number: TGM-T79036-100mg
Description: Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1]. Target: Others
| Application: | Mcl-1 inhibitor |
| CAS | 2445466-06-6 |
| MW: | 858.35 D |
From 1,583.00€
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CDK9-IN-23
Item number: TGM-T79037-50mg
Description: CDK9-IN-23 (Example 4) is a highly potent CDK9 inhibitor with an IC50 value below 20 nM [1]. Target: CDK
| CAS | 2761572-96-5 |
| MW: | 428.91 D |
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Tau protein aggregation-IN-1
Item number: TGM-T79038-100mg
Description: Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease, and prion-based spongiform encephalopathies [1]. Target: Others
| CAS | 916179-45-8 |
| MW: | 355.19 D |
From 1,440.00€
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GGGDTDTC-Mc-vc-PAB-MMAE
Item number: TGM-T79039-50mg
Description: GGGDTDTC-Mc-vc-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), containing monomethyl auristatin E (MMAE), a tubulin inhibitor, as the cytotoxic component [1]. Target: Drug-Linker Conjugates for ADC, Others
| MW: | 2040.34 D |
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TRV-1387
Item number: TGM-T79040-50mg
Description: TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-beta [1]. Target: Others
| CAS | 1569645-63-1 |
| MW: | 446.47 D |
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RIP1 kinase inhibitor 4
Item number: TGM-T79041-100mg
Description: RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of = 1000 nM [1]. Target: RIP kinase
| Application: | RIP1 kinase inhibitor |
| CAS | 2919836-00-1 |
| MW: | 369.46 D |
From 1,725.00€
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