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Ppardelta agonist 5
Item number: TGM-T62646-100mg
Description: Ppardelta agonist 5 is a selective, orally active PPARdelta agonist with an EC50 of 0.335 µM and better selectivity than GW0742. Ppardelta agonist 5 has a beneficial effect on the improvement of bone density and microarchitecture in vivo. Target: Others
| MW: | 446.49 D |
From 1,440.00€
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HDAC-IN-34
Item number: TGM-T62649-100mg
Description: HDAC-IN-34 (compound 27) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.022 µM) and HDAC6 (IC50: 0.45 µM). It can bind to DNA and induce DNA damage, exhibiting a significant anti-proliferative effect on HCT-116 cells (IC50: 1.41 µM). Target: Others
| MW: | 446.5 D |
From 1,440.00€
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ATR-IN-11
Item number: TGM-T62651-100mg
Description: ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinases. As a promising lead compound for developing drugs targeting the ATR kinase, a key regulatory protein in the DNA damage response (DDR) that senses replication stress (RS), ATR-IN-11 has significant...
| MW: | 446.54 D |
From 1,440.00€
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Cathepsin C-IN-4
Item number: TGM-T62659-100mg
Description: Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM). Target: Others
| MW: | 446.88 D |
From 1,440.00€
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FAAH/MAGL-IN-3
Item number: TGM-T62671-100mg
Description: FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) with an IC50 of 179 nM for FAAH and 759 nM for MAGL. FAAH/MAGL-IN-3 exhibited minimal permeability in the PAMPA (parallel artificial membrane permeability assay)....
| MW: | 447.5 D |
From 1,440.00€
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Antiviral agent 15
Item number: TGM-T62780-100mg
Description: Antiviral agent 15 (Compound 15f) is a Clofazimine derivative with antiviral activity, inhibiting the rabies virus (EC50: 1.45 µM) and pseudotyped SARS-CoV-2 (EC50: 14.6 µM). Target: Others
| MW: | 453.51 D |
From 1,440.00€
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HDAC1-IN-3
Item number: TGM-T62786-100mg
Description: HDAC1-IN-3 is a potent inhibitor of Pf HDAC1, exhibiting a significant in vivo killing effect on all life cycles of the parasite and displaying antimalarial activity in both wild-type and multidrug-resistant strains of the parasite. Target: Others
| MW: | 453.92 D |
From 1,440.00€
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14alpha-Demethylase/DNA Gyrase-IN-1
Item number: TGM-T62792-100mg
Description: 14alpha-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14alpha-Demethylase/DNA Gyrase, exhibiting antibacterial activity. Target: Others
| MW: | 454.48 D |
From 1,440.00€
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EB-0150
Item number: TGM-T62793-100mg
Description: EB-0150 is a potent inhibitor of ER alpha-glucosidase (alpha-Glu) I (IC50: 0.73 µM) and (alpha-Glu) II (IC50: 0.0337 µM), and is an N-substituted valerian derivative with broad-spectrum antiviral effects, holding potential for broad-spectrum drug discovery against existing and emerging viruses and for...
| MW: | 454.48 D |
From 1,440.00€
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VEGFR-2-IN-13
Item number: TGM-T62796-100mg
Description: VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor (IC50: 3.4 nM) that arrests the HepG2 cell cycle in the G2/M phase and induces apoptosis. Target: Others
| MW: | 454.5 D |
From 1,440.00€
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FLT3/TrKA-IN-1
Item number: TGM-T62801-100mg
Description: FLT3/TrKA-IN-1 is a potent dual kinase inhibitor that targets FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM), and TrKA (IC50: 23.6 nM). FLT3/TrKA-IN-1 shows potential for acute myeloid leukaemia (AML) studies. Target: Others
| MW: | 454.56 D |
From 1,440.00€
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Indoluidin E
Item number: TGM-T62802-100mg
Description: Indoluidin E selectively inhibits DHODH and effectively suppresses cancer cell growth. Target: Others
| MW: | 454.56 D |
From 1,440.00€
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