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PSB-603
Item number: Cay25637-1
PSB-603 is an antagonist of the adenosine A2B receptor (Ki = 0.553 nM). It is selective for adenosine A2B over A1, A2A, and A3 receptors (Kis = >10,000 nM). It reduces intracellular calcium concentrations in Jurkat T cells expressing the human A2B receptor (IC50 = 1.13 nM). PSB-603 reduces Zika viral plaque...
| Keywords: | 8-[4-[[4-(4-chlorophenyl)-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl-1H-purine-2,6-dione |
| Application: | Adenosine receptor A2b antagonist |
| CAS | 1092351-10-4 |
| MW: | 529 D |
From 59.00€
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Torin 1
Item number: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Keywords: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Application: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
From 224.00€
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Nitroblue Tetrazolium Chloride (NBT)
Item number: 06428.1
and other oxygenases. Often used in conjunction with BCIP (02291) for AP staining.
| Application: | Substrate for dehydrogenases |
| CAS | 298-83-9 |
| MW: | 817.64 |
From 158.00€
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G-418 (sulfate)
Item number: Cay13200-5
G-418 is an aminoglycoside antibiotic. It is active against T. thermophila (IC50 = 10 µM). It inhibits the 80S ribosome and protein elongation during translation in a cell-free assay when used at a concentration of 2 nM. G-418 is used in molecular biology as a selective agent in cell lines or plasmids containing the...
| Keywords: | Geneticin,... |
| Application: | Antibiotic |
| CAS | 108321-42-2 |
| MW: | 692.7 D |
From 87.00€
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Fluo-4 AM *Ultrapure Grade*
Item number: ABD-20551
Fluo-4 is an analog of Fluo-3 with the two chlorine substituents replaced by fluorines, which results in increased fluorescence excitation at 488 nm and consequently higher fluorescence signal levels. Cells may be loaded with the AM ester forms of these calcium indicators by adding the dissolved indicator directly...
| Application: | Fluorescent Ca2+ probe |
| CAS | 273221-67-3 |
| MW: | 1096.95 D |
From 145.00€
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Wortmannin
Item number: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
| Keywords: | KY 12420,... |
| Application: | PI3K inhibitor |
| CAS | 19545-26-7 |
| MW: | 428.4 D |
From 74.00€
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alpha-Hydroxymidazolam
Item number: Cay10385-5
alpha-Hydroxymidazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.Formal Name: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol. CAS Number: 59468-90-5. Synonyms:...
| Keywords: | Ro 21-6347, alpha-Hydroxymidazolam, 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol |
| CAS | 59468-90-5 |
| MW: | 341.8 D |
From 223.00€
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PD 0325901
Item number: Cay13034-25
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...
| Keywords: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Application: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482.2 D |
From 76.00€
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MG-132
Item number: AG-CP3-0011-M005
Soluble in DMSO or ethanol. Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin...
| Keywords: | Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, MG132 |
| Application: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 476 D |
From 22.00€
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Kifunensine
Item number: Cay10009437-1
Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase. It has since been shown to be a potent and selective inhibitor of class I alpha-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis. Kifunensine...
| Keywords: | FR900494, hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione |
| Application: | Alpha-mannosidase inhibitor |
| CAS | 109944-15-2 |
| MW: | 232.2 D |
From 104.00€
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3-Deazaneplanocin A
Item number: Cay13828-1
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
| Keywords: | DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Application: | S-adenosyl-L-homosysteine hydrolase inhibitor |
| CAS | 102052-95-9 |
| MW: | 262.3 D |
From 149.00€
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Erlotinib
Item number: Cay10483-250
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...
| Keywords: | NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| Application: | Tyrosine kinase inhibitor |
| CAS | 183321-74-6 |
| MW: | 393.4 D |
From 51.00€
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