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Oxibendazole
Item number: TGM-T6623-100mg
Description: Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets. Target: Parasite, Apoptosis. Smiles: N(C(OC)=O)C=1NC=2C(N1)=CC(OCCC)=CC2. References: Lyons ET,...
| Application: | Anthelmintic |
| CAS | 20559-55-1 |
| MW: | 249.27 D |
From 30.00€
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Ethyl...
Item number: TGM-T66256-100mg
Description: Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism. Target:...
| CAS | 503614-91-3 |
| MW: | 488.54 D |
From 34.00€
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PF-3758309
Item number: TGM-T6626-10mg
Description: PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition. Target: Apoptosis, PAK. Smiles: CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1. References: Murray BW, et al. Proc Natl Acad Sci U S A, 2010, 107(20), 9446-9451.
| Keywords: | PF-309, PF-03758309, PF 3758309 |
| Application: | ATP-competitive PAK4 inhibitor |
| CAS | 898044-15-0 |
| MW: | 490.62 D |
From 52.00€
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Pirarubicin
Item number: TGM-T6628-100mg
Description: Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic agent. Target: Antibacterial, Autophagy, Antibiotic, Topoisomerase. Smiles:...
| Keywords: | Theprubicin, THP |
| Application: | Targets DNA topoisomerase II [EC:5.6.2.2] (TOP2) |
| CAS | 72496-41-4 |
| MW: | 627.64 D |
From 31.00€
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PYR-41
Item number: TGM-T6629-100mg
Description: PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. Target: Apoptosis, E1/E2/E3 Enzyme. Smiles: CCOC(=O)c1ccc(cc1)N1NC(=O)\C(=C\c2ccc(o2)[N+]([O-])=O)C1=O. References: Yang Y, et al. Cancer Res, 2007, 67(19), 9472-9481.
| Keywords: | PYR 41, PYR41 |
| Application: | Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor |
| CAS | 418805-02-4 |
| MW: | 371.3 D |
From 32.00€
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Quinine hydrochloride dihydrate
Item number: TGM-T6631-1g
Description: Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria. Target: Parasite, Potassium Channel. Smiles: O.O.Cl.COc1ccc2nccc([C@@H](O)C3C[C@H]4CCN3C[C@@H]4C=C)c2c1. References: Srinivas M, et al. Proc Natl Acad Sci U S A,2001, 98(19),...
| Keywords: | Quinine HCl Dihydrate |
| Application: | Antimalarial |
| CAS | 6119-47-7 |
| MW: | 396.91 D |
29.00€
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Raltitrexed
Item number: TGM-T6632-100mg
Description: Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth. Target: DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog. Smiles: O=C1C=2C(=CC=C(CN(C)C=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3)C2)NC(C)=N1. References: Peters GJ, et al. Eur J Cancer,...
| Keywords: | Tomudex, ZD1694, D1694, ICI-D1694 |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 112887-68-0 |
| MW: | 458.49 D |
From 30.00€
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Ranolazine
Item number: TGM-T6633-100mg
Description: Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level. Target: Calcium Channel, Sodium Channel. Smiles:...
| Keywords: | CVT 303, Ranexa, RS 43285-003 |
| Application: | Vasodilator |
| CAS | 95635-55-5 |
| MW: | 427.54 D |
From 48.00€
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6-HEX
Item number: TGM-T66330-100mg
Description: 6-HEX is a useful organic compound for research related to life sciences. The catalog number is T66330 and the CAS number is 155911-16-3. Target: Others. Smiles: OC(=O)c1cc(Cl)c2C(=O)OC3(c2c1Cl)c1cc(Cl)c(O)c(Cl)c1Oc1c(Cl)c(O)c(Cl)cc31
| CAS | 155911-16-3 |
| MW: | 582.97 D |
From 34.00€
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RBC8
Item number: TGM-T6634-100mg
Description: RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras. Target: Ras, GTPase. Smiles: COc1ccc(OC)c(c1)C1c2c(OC(N)=C1C#N)[nH]nc2-c1ccc2ccccc2c1. References: Yan C, et al. Nature. 2014, 515(7527), 443-447.
| Application: | RalA / RalB inhibitor |
| CAS | 361185-42-4 |
| MW: | 424.45 D |
From 39.00€
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EMD638683
Item number: TGM-T6635-100mg
Description: EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 µM). Target: SGK. Smiles: CCc1c(C)c(O)ccc1C(=O)NNC(=O)C(O)c1cc(F)cc(F)c1. References: Towhid S T , Liu G L , Ackermann T F , et al. Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683[J]. Cellular...
| Application: | Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor |
| CAS | 1181770-72-8 |
| MW: | 364.34 D |
From 84.00€
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Refametinib
Item number: TGM-T6636-100mg
Description: Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). Target: MEK. Smiles: S(NC1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1OC)(=O)(=O)C3(C[C@@H](CO)O)CC3. References: Liu D, et al, Int J Cancer, 2010, 127(12), 2965-2973.
| Keywords: | BAY 86-97661 , BAY 869766 , RDEA119 |
| Application: | MEK1/2 inhibitor |
| CAS | 923032-37-5 |
| MW: | 572.34 D |
From 30.00€
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