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Licofelone
Item number: TGM-T6568-100mg
Description: Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for treating osteoarthritis, acting as both an analgesic and anti-inflammatory. By inhibiting 5-LOX, it may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX...
| Keywords: | ML-3000 |
| CAS | 156897-06-2 |
| MW: | 379.88 D |
From 38.00€
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L-NAME hydrochloride
Item number: TGM-T6570-10g
Description: L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS) with an IC50 of 70 µM, and it can be used to induce hypertension and kidney injury models. Target: NO Synthase, NOS. Smiles: Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O. References: Rees DD, et al. Br J Pharmacol, 1990, 101(3), 746-752.
| Keywords: | L-NAME HCl , N(G)-Nitro-L-arginine methyl ester , NG-Nitroarginine methyl ester hydrochloride |
| MW: | 269.69 D |
From 30.00€
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Lomerizine dihydrochloride
Item number: TGM-T6571-100mg
Description: Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine. Target: Calcium Channel. Smiles: Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC. References: Tamaki Y, et al. Invest Ophthalmol Vis Sci, 2003, 44(11), 4864-4871.
| Keywords: | Lomerizine hydrochloride , Lomerizine 2HCl , Terranas , KB-2796 |
| Application: | Antimigraine, Vasoconstriction suppressant |
| CAS | 101477-54-7 |
| MW: | 541.46 D |
From 29.00€
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E 64c
Item number: TGM-T6573-100mg
Description: E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. Target: Cysteine Protease, SARS-CoV. Smiles: CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O. References: McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435.
| Keywords: | EP 475, NSC 694279, Loxistatin Acid |
| CAS | 76684-89-4 |
| MW: | 314.38 D |
From 45.00€
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Lumiracoxib
Item number: TGM-T6574-10mg
Description: Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 µM and 0.06 µM, exhibits 515-fold selectivity over COX-1. Phase 4. Target: COX. Smiles: N(C1=C(CC(O)=O)C=C(C)C=C1)C2=C(Cl)C=CC=C2F. References: Esser R, et al. Br J Pharmacol, 2005, 144(4), 538-550.
| Keywords: | COX-189, Prexige |
| Application: | Targets prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1] (PTGS2, COX2) |
| CAS | 220991-20-8 |
| MW: | 293.72 D |
From 30.00€
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Trityl candesartan
Item number: TGM-T65740-100mg
Description: Trityl candesartan is a crucial intermediate used in the synthesis of Candesartan and Candesartan cilexetil, which are angiotensin II receptor antagonists. Target: Others. Smiles: CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1. References: Islas...
| CAS | 139481-72-4 |
| MW: | 682.77 D |
From 38.00€
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LY2119620
Item number: TGM-T6575-100mg
Description: LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. Target: AChR. Smiles: CN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl. References: Croy CH, et al. Mol Pharmacol. 2014, 86(1), 106-115.
| Application: | Muscarinic acetylcholine receptor M2 / M4 positive allosteric modulator (PAM) |
| CAS | 886047-22-9 |
| MW: | 437.94 D |
From 49.00€
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ME0328
Item number: TGM-T6578-100mg
Description: ME0328 is a potent, selective PARP inhibitor with an IC50 of 0.89 µM for PARP3, showing approximately 7-fold selectivity over PARP1. Target: PARP. Smiles: C[C@H](NC(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccccc1. References: Lindgren AE, et al. ACS Chem Biol. 2013, 8(8), 1698-1703.
| Application: | PARP3 inhibitor |
| CAS | 1445251-22-8 |
| MW: | 321.37 D |
From 40.00€
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Medetomidine hydrochloride
Item number: TGM-T6579-100mg
Description: Medetomidine hydrochloride (MPV785) is a selective alpha2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over alpha1-adrenoceptor. Target: Adrenergic Receptor. Smiles: Cl.CC(c1c[nH]cn1)c1cccc(C)c1C. References: MacDonald E, et al. Eur J Pharmacol, 1988, 158(1-2), 119-127.
| Keywords: | MPV785 , Medetomidine HCl , Domitor |
| Application: | Analgesic (veterinary), Sedative (veterinary), alpha2-Adrenergic receptor agonist |
| CAS | 86347-15-1 |
| MW: | 236.74 D |
From 30.00€
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Meprednisone
Item number: TGM-T6580-100mg
Description: Betapar(Meprednisone (Betapar)) is a glucocorticoid and a methylated derivative of prednisone. Target: Glucocorticoid Receptor, Autophagy. Smiles: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO. References: Rubinsztein DC, Bento CF, Deretic V.J Exp Med. 2015 Jun...
| Keywords: | SCH 4358 , Methylprednisone , NSC 527579 , Betanisona , Betapar |
| Application: | Targets glucocorticoid receptor (NR3C1, GR) |
| CAS | 1247-42-3 |
| MW: | 372.45 D |
From 30.00€
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Methyclothiazide
Item number: TGM-T6581-10mg
Description: Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. Target: Carbonic Anhydrase, Others. Smiles: O=S1(=O)C=2C(NC(CCl)N1C)=CC(Cl)=C(S(N)(=O)=O)C2. References: Colas B, et al. Eur J...
| Keywords: | Aquatensen, Enduron, Duretic |
| Application: | Targets solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3, TSC) |
| CAS | 135-07-9 |
| MW: | 360.24 D |
From 29.00€
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Mezlocillin Sodium
Item number: TGM-T6582-100mg
Description: Mezlocillin Sodium (Baycipen) is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Target: Antibacterial, Antibiotic. Smiles:...
| Keywords: | Baycipen |
| CAS | 42057-22-7 |
| MW: | 561.56 D |
From 34.00€
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