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4-FPBUA
Item number: TGM-T89888-10mg
Description: 4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of beta-amyloid (Abeta) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB...
| MW: | 526.51 D |
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Adenosine receptor agonist 1
Item number: TGM-T89890-10mg
Description: Compound 6m, an A3 adenosine receptor (AR) partial agonist, exhibits a K i value of 6.7 nM as an adenosine receptor agonist. Target: Adenosine Receptor
| MW: | 374.68 D |
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E3 Ligase Ligand-linker Conjugate 115
Item number: TGM-T89899-10mg
Description: E3 Ligase Ligand-linker Conjugate 115, a type of E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates), is utilized in the synthesis of PROTAC SMARCA2/4-degrader-27. Smiles:...
| MW: | 708.84 D |
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Sigma-1 receptor antagonist 6
Item number: TGM-T89901-10mg
Description: Sigma-1 receptor antagonist 6 (Compound 12), a sigma1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (sigma1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel. Target:...
| MW: | 502.65 D |
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AURKA against 1
Item number: TGM-T89903-10mg
Description: Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by...
| MW: | 545.61 D |
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PPARgamma-IN-3
Item number: TGM-T89904-10mg
Description: PPARgamma-IN-3 (compound 9ga), a potent and orally active PPARgamma inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood....
| MW: | 469.51 D |
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YLL545
Item number: TGM-T89909-10mg
Description: YLL545 is an inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2). It inhibits VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling mediators (such as phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC)....
| MW: | 414.34 D |
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BMS986188
Item number: TGM-T8992-200mg
Description: BMS986188 is a novel Potent and Selective Positive Allosteric Modulator of the delta-Opioid Receptor. Target: Opioid Receptor. Smiles: O=C1C=2C(C3=C(OC2CC(C)(C)C1)CC(C)(C)CC3=O)C4=CC=C(OCC5=C(Br)C=CC=C5)C=C4
| MW: | 535.47 D |
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CEP1347-VHL-02
Item number: TGM-T89921-10mg
Description: CEP1347-VHL-02 is a PROTAC that selectively targets MLK3. This compound is composed of the target protein ligand CEP-1347, the E3 ubiquitin ligase ligand (S,R,S)-AHPC-Me, and the PROTAC linker Amino-PEG3-CH2COOH. The participating component responsible for controlling the target protein ligand activity...
| MW: | 1189.47 D |
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3,5-DiBr-PAESA sodium
Item number: TGM-T89922-10mg
Description: 3,5-DiBr-PAESA (sodium) serves as an ultrasensitive chelating agent specifically designed for the detection of silver (I) in water, ensuring accuracy even without the presence of interfering ions. Additionally, it is applicable for the determination of copper (II). Smiles:...
| MW: | 528.19 D |
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Neptinib
Item number: TGM-T89923-10mg
Description: Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib...
| Keywords: | NEP010 |
| MW: | 443.9 D |
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HMGB1-IN-3
Item number: TGM-T89924-10mg
Description: HMGB1-IN-3 (compound E), a derivative of glycyrrhizic acid, exhibits potent inhibitory effects on HMGB1 (high mobility group protein 1). It is utilized in research related to intracerebral hemorrhage. Target: Others. Smiles:...
| MW: | 482.69 D |
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