No results were found for the filter!
NEW
Boc-Cystamine-Poc
Item number: TGM-T89823-10mg
Description: Boc-Cystamine-Poc is a click chemistry reagent featuring a cystamine structural unit. Target: ADC Linker. Smiles: O=C(OCC#C)NCCSSCCNC(=O)OC(C)(C)C
| MW: | 334.46 D |
Please request pricing for this article.
NEW
TY-011
Item number: TGM-T89833-10mg
Description: TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer...
| MW: | 337.81 D |
Please request pricing for this article.
NEW
Thalidomide-azetidin-3-one
Item number: TGM-T89837-10mg
Description: Thalidomide-azetidin-3-one serves as an E3 Ligase Ligand-Linker Conjugate and facilitates the synthesis of PROTAC PD-L1 degrader-2. Smiles: O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CC(=O)C4
| MW: | 327.29 D |
Please request pricing for this article.
NEW
2-Thio-6-azauridine
Item number: TGM-T89843-100mg
Smiles: O[C@H]1[C@H](N2C(NC(C=N2)=O)=S)O[C@@H]([C@H]1O)CO
| MW: | 261.255 D |
Please request pricing for this article.
NEW
BRD4-IN-9
Item number: TGM-T89853-10mg
Description: BRD4-IN-9, an orally active BRD4 inhibitor, demonstrates a potent IC50 of 9.4 nM. In a murine melanoma xenograft model, it effectively inhibits tumor growth. Target: Others. Smiles: O=C1C=CC(=CN1C)C=2C=CC=3N=C(NC3C2OC=4C=CC=CC4)C5CCOCC5
| MW: | 401.46 D |
Please request pricing for this article.
NEW
TfR-1-IN-1
Item number: TGM-T89857-1mg
Description: TfR-1-IN-1 is a transferrin receptor 1 (TfR-1) inhibitor, also an Fe(III) salivary phenol complex, with anticancer activity. It induces apoptosis, inhibits the growth of tumor cells and normal cells, and is used in studies of leukemia. Target: Ferroptosis. Smiles:...
| MW: | 441.62 D |
661.00€
*
NEW
MTT5
Item number: TGM-T89866-10mg
Description: MTT5, a toll-like receptor 7 (TLR7) agonist, can be conjugated with Deruxtecan to exert antitumor activity in HER2-positive solid tumors through tumor cell killing and immune activation.
| MW: | 453.49 D |
Please request pricing for this article.
NEW
WQQ-345
Item number: TGM-T89876-10mg
Description: WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces alpha-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive...
| MW: | 183.25 D |
Please request pricing for this article.
NEW
Kv7.2/Kv7.3 activator-1
Item number: TGM-T89880-10mg
Description: Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research. Target: Potassium Channel. Smiles: N#CC=1C=C(F)C=2N=C(NC(=O)CC(C)(C)C)N(C2C1F)C3(C)CCC3
| MW: | 360.4 D |
Please request pricing for this article.
NEW
ADP-specific glucokinase
Item number: TGM-T89882-10mg
Description: ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to...
| Keywords: | ADP-dependent hexokinase |
Please request pricing for this article.
NEW
JNU-0921
Item number: TGM-T89884-10mg
Description: JNU-0921, as a CD137 activator, exhibits highly efficient oral activity. It enhances the mRNA expression of IFN-gamma and GZMB and induces luciferase activity with an EC50 of 64.07 nM. JNU-0921 also boosts both the efficacy and memory function of cytotoxic CD8+ T cells (CTL), alleviating their...
| MW: | 316.31 D |
Please request pricing for this article.
NEW
PF-05661014
Item number: TGM-T89885-10mg
Description: PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation. Target: Sodium Channel. Smiles:...
| MW: | 388.46 D |
Please request pricing for this article.