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Exatecan Intermediate 6
Item number: TGM-T89644-10mg
Description: Exatecan Intermediate 6 serves as an intermediate in the synthesis of Exatecan (DX-8951), a DNA topoisomerase I inhibitor with an IC50 value of 2.2 µM (0.975 µg/mL), utilized in cancer research. Additionally, Exatecan Intermediate 6 is employed in the preparation of Antibody-Drug Conjugates (ADCs)....
| MW: | 235.25 D |
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SN-38-d3
Item number: TGM-T89645-10mg
Description: SN-38-d3 is a deuterated form of SN-38. As the active metabolite of the topoisomerase I (TopoisomeraseI) inhibitor irinotecan, SN-38 (NK012) notably inhibits the synthesis of DNA and RNA, with IC50 values of 0.077 and 1.3 µM, respectively. Target: ADC Cytotoxin. Smiles:...
| MW: | 395.42 D |
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Taltobulin intermediate-4
Item number: TGM-T89648-10mg
Description: Taltobulinintermediate-4 is an intermediate used in the synthesis of Taltobulin, a common toxin component (ADC Cytotoxin) in ADC preparation and a potent inhibitor of microtubule/tubulin (Microtubule/Tubulin). Taltobulin disrupts the polymerization of microtubules, induces mitotic arrest, and triggers...
| MW: | 412.56 D |
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PF-06380101-d8
Item number: TGM-T89649-10mg
Description: PF-06380101-d8 is a deuterated version of PF-06380101, an Auristatin microtubule inhibitor and a cytotoxic Dolastatin 10 analog. Target: ADC Cytotoxin
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Camptothecin-d5
Item number: TGM-T89650-10mg
Description: Camptothecin-d5 is a deuterated derivative of Camptothecin (CPT), an alkaloid and an inhibitor of DNA topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) exhibits potent antitumor activity against colorectal, breast, lung, and ovarian cancers by modulating the expression pattern of...
| MW: | 353.38 D |
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DM4-d6
Item number: TGM-T89651-10mg
Description: DM4-d6 is a deuterated form of DM4, an antimicrotubule agent that inhibits cell division. DM4 is utilized in the preparation of antibody-drug conjugates (ADCs). Target: ADC Cytotoxin
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7-Hydroxymethyl-10,11-MDCPT-d5
Item number: TGM-T89652-10mg
Description: 7-Hydroxymethyl-10,11-MDCPT-d5 is a deuterated derivative of 7-Hydroxymethyl-10,11-MDCPT, serving as an efficacious payload for ADC (Antibody Drug Conjugate) synthesis. Target: ADC Cytotoxin
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Biotin-PEG(4)-SS-Azide
Item number: TGM-T89664-10mg
Description: Biotin-PEG(4)-SS-Azide, a click chemistry reagent featuring an azide group, is utilized in various biochemical research applications. Target: ADC Linker. Smiles: C(CCCC(NCCOCCOCCO CCOCCC(NCCSSCCC(NCCCN=[N+]=[N-])=O)=O)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
| MW: | 736.97 D |
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Fmoc-D-Aha-OH
Item number: TGM-T89665-10mg
Description: Fmoc-D-Aha-OH is a click chemistry reagent featuring an azide functional group. This compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can react in strain-promoted azide-alkyne cycloaddition reactions...
| MW: | 366.37 D |
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Fmoc-L-Tyr(2-azidoethyl)-OH
Item number: TGM-T89668-10mg
Description: Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent featuring an azido group. This synthetic derivative of tyrosine, protected by an Fmoc group, includes an azidoethyl substituent functioning as a reactive handle for dual orthogonal conjugation via Cu(I)-catalyzed 1,3-dipolar cycloaddition with...
| MW: | 472.49 D |
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Fmoc-L-MeLys(N3)-OH
Item number: TGM-T89669-10mg
Description: Fmoc-L-MeLys(N3)-OH is a click chemistry reagent featuring an azide functional group. This compound serves as an SPPS building block for the incorporation of N-Me-Lys, which can be modified through azide groups via click chemistry. Fmoc-L-MeLys(N3)-OH can undergo copper-catalyzed azide-alkyne...
| MW: | 408.45 D |
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Poc-Cystamine
Item number: TGM-T89672-10mg
Description: Poc-Cystamine is a click chemistry reagent consisting of a cystamine structural unit derived from a propargyl group. Target: ADC Linker. Smiles: O=C(OCC#C)NCCSSCCN
| MW: | 234.34 D |
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