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TCO-PEG3-amide-C3-triethoxysilane
Item number: TGM-T18764-100mg
Description: TCO-PEG3-amide-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1]. Target: Others. Smiles: CCO[Si](CCCNC(=O)CCOCCOCCOC CNC(=O)OC1CCCC=CCC1)(OCC)OCC , w:30.30, . References: An S, et al. Small-molecule PROTACs: An emerging...
| CAS | 2250217-32-2 |
| MW: | 576.803 D |
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TCO-PEG3-amine
Item number: TGM-T18765-100mg
Description: TCO-PEG3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles: NCCOCCOCCO CCNC(=O)OC1CCCC=CCC1 , w:21.21, ....
| CAS | 1800507-93-0 |
| MW: | 344.452 D |
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TCO-PEG3-Biotin
Item number: TGM-T18766-1mg
Description: TCO-PEG3-Biotin is a cleavable ADC linker composed of three PEG units, primarily used in synthesizing antibody-drug conjugates (ADCs) [1]. Target: Others, ADC Linker. Smiles: O=C(NCCOCCOCCO CCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)O[C@H]3CCC/C([H])=C/CC3. References: Beck A, et al. Strategies and...
| MW: | 570.74 D |
From 183.00€
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TCO-PEG3-maleimide
Item number: TGM-T18767-100mg
Description: TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Target: ADC Linker, Others. Smiles: O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCO CCNC(CCN2C(C=CC2=O)=O)=O. References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development...
| MW: | 495.57 D |
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TCO-PEG3-NHS ester
Item number: TGM-T18768-100mg
Description: TCO-PEG3-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system [in cells]. Target: Others. Smiles: O=C(CCOCCOCCOC CNC(=O)OC1CCCC=CCC1)ON1C(=O)CCC1=O , w:22.22, ....
| CAS | 2141981-88-4 |
| MW: | 470.519 D |
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TCO-PEG3-oxyamine
Item number: TGM-T18769-100mg
Description: TCO-PEG3-oxyamine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells. Target: Others. Smiles: NOCC(NCCOCCOCCO CCNC(O[C@H]1CCC/C([H])=C/CC1)=O)=O. References: An S, et al. Small-molecule...
| MW: | 417.5 D |
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LH846
Item number: TGM-T1877-10mg
Description: LH846 is a selective inhibitor of CK1delta with IC50 values of 290 nM for CK1delta, 1.3 µM for CK1epsilon, and 2.5 µM for CK1alpha, and exhibits no inhibitory activity at CK2. Target: Casein Kinase. Smiles: Cc1cc2sc(NC(=O)Cc3ccccc3)nc2cc1Cl. References: Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov...
| Keywords: | LH 846, LH-846 |
| Application: | CSNK1D inhibitor |
| CAS | 639052-78-1 |
| MW: | 316.81 D |
From 55.00€
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TCO-PEG3-TCO
Item number: TGM-T18770-100mg
Description: TCO-PEG3-TCO is a PEG-based linker crucial for PROTAC molecules, as it connects two essential ligands. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system [in cells]. Target: Others. Smiles: O=C(NCCOCCOCCO CCNC(=O)OC1CCCC=CCC1)OC1CCCC=CCC1 , w:32.33,23.23,...
| CAS | 2243569-22-2 |
| MW: | 496.645 D |
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TCO-PEG36-acid
Item number: TGM-T18771-100mg
Description: TCO-PEG36-acid is a PEG-based linker for PROTACs (proteolysis-targeting chimeras) that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells. Target: Others. Smiles: O=C(OC1CC/C=C\CCC1)NCCOCCOCCO CCOCCOCCOC COCCOCCOCC OCCOCCOCCO...
| MW: | 1827.18 D |
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TCO-PEG4-amine
Item number: TGM-T18772-100mg
Description: TCO-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation by leveraging the ubiquitin-proteasome system within cells. [PROTACs]. Target: Others. Smiles: NCCOCCOCCO CCOCCNC(=O)OC1CCCC=CCC1 , w:24.24, . References: Wang Y, et al....
| CAS | 2243569-24-4 |
| MW: | 388.505 D |
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TCO-PEG4-DBCO
Item number: TGM-T18773-100mg
Description: TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Target: Others, ADC Linker. Smiles: O=C(CCOCCOCCOC COCCNC(=O)OC1CCC\C=C/CC1)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12. References: Rahim MK, et al. Enhancing reactivity for bioorthogonal pretargeting by unmasking...
| CAS | 1801863-88-6 |
| MW: | 675.823 D |
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TCO-PEG4-TCO
Item number: TGM-T18774-100mg
Description: TCO-PEG4-TCO is a PEG-based linker used in PROTACs that connects two ligands critical for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells. Target: Others. Smiles: O=C(NCCOCCOCCO CCOCCNC(=O)OC1CCCC=CCC1)OC1CCCC=CCC1 , w:35.36,26.26, ....
| CAS | 2243569-23-3 |
| MW: | 540.698 D |
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