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TAMRA-PEG4-methyltetrazine
Item number: TGM-T18748-100mg
Description: TAMRA-PEG4-methyltetrazine is a polyethylene glycol (PEG)-based linker employed for synthesizing proteolysis targeting chimeras (PROTACs)[1]. Target: Others. Smiles: O=C([O-])C=1C=C(C=CC1C=2C=3C=CC(=CC3[O+]=C4C=C(C=CC42)N(C)C)N(C)C)C(=O)NCCOCCOCCO CCOC=5C=CC(=CC5)C6=NN=C(N=N6)C. References: An S, et al....
| CAS | 2163772-19-6 |
| MW: | 775.85 D |
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TAMRA-PEG4-tetrazine
Item number: TGM-T18749-100mg
Description: TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles: [O-]C(C(C=C(C(NCCOCCOCCO...
| MW: | 846.94 D |
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N-Deshydroxyethyl Dasatinib
Item number: TGM-T18750-100mg
Description: N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases. Target: Others, Drug...
| Keywords: | N-Deshydroxyethyl BMS-354825 |
| CAS | 910297-51-7 |
| MW: | 443.95 D |
From 48.00€
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TCO-OH
Item number: TGM-T18751-2mg
Description: TCO-OH is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles: OC1CCC\C=C\CC1. References: An S, et al....
| CAS | 85081-69-2 |
| MW: | 126.2 D |
75.00€
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TCO-PEG1-Val-Cit-OH
Item number: TGM-T18753-100mg
Description: TCO-PEG1-Val-Cit-OH is a cleavable 1-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Target: Others, ADC Linker. Smiles: OC([C@H](CCCNC(N)=O)NC([C@@H](C(C)C)NC(CCOCCNC(OC1CCCC/C=C/C1)=O)=O)=O)=O. References: Beck A, et al. Strategies and challenges...
| MW: | 541.64 D |
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TCO-PEG1-Val-Cit-PABC-OH
Item number: TGM-T18754-100mg
Description: TCO-PEG1-Val-Cit-PABC-OH, a cleavable 1-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Target: ADC Linker, Others. Smiles: O=C(OC1CCCC/C=C/C1)NCCOCCC(N[C@@H](C(N[C@H](C(NC2=CC=C(C=C2)CO)=O)CCCNC(N)=O)=O)C(C)C)=O. References: Beck A, et al. Strategies and...
| MW: | 646.77 D |
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TCO-PEG11-TCO
Item number: TGM-T18755-100mg
Description: TCO-PEG11-TCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles:...
| MW: | 849.06 D |
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TCO-PEG12-NHS ester
Item number: TGM-T18756-100mg
Description: TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Target: Others, ADC Linker. Smiles: O=C(CCOCCOCCOC COCCOCCOCC OCCOCCOCCO CCOCCOCCNC(=O)OC1CCCC=CCC1)ON1C(=O)CCC1=O , w:49.49, . References: Leon S. FARHI, et al. Compositions and methods for...
| CAS | 2185016-39-9 |
| MW: | 866.996 D |
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TCO-PEG12-TFP ester
Item number: TGM-T18757-100mg
Description: TCO-PEG12-TFP ester is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells. Target: Others. Smiles: O=C(OC1CC/C=C\CCC1)NCCOCCOCCO CCOCCOCCOC COCCOCCOCC...
| MW: | 917.97 D |
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TCO-PEG2-amine
Item number: TGM-T18758-2mg
Description: TCO-PEG2-amine is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells. Target: Others. Smiles: NCCOCCOCCNC(=O)OC1CCC\C=C/CC1. References: Wang Y, et al. Degradation of proteins...
| CAS | 2141981-87-3 |
| MW: | 300.399 D |
From 54.00€
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TCO-PEG2-Sulfo-NHS ester
Item number: TGM-T18759-100mg
Description: TCO-PEG2-Sulfo-NHS ester is a Polyethylene glycol (PEG)-based linker for PROTAC synthesis[1]. Target: ADC Linker, Others. Smiles: CCNC(=O)NCCCN(C)C.OS(=O)(=O)C1CC(=O)N(OC(=O)CCOCCOCCNC(=O)OC2CCCC=CCC2)C1=O , w:41.40, . References: An S, et al. Small-molecule PROTACs: An emerging and promising approach...
| CAS | 2353409-48-8 |
| MW: | 679.78 D |
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Kobe0065
Item number: TGM-T1876-100mg
Description: Kobe0065 is a novel and effective small-molecule compound that inhibits the Ras-Raf interaction by structure-based drug design (SBDD), it displays potent activity, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 µM. Target: Raf, Apoptosis, Ras. Smiles:...
| Application: | Ras inhibitor |
| CAS | 436133-68-5 |
| MW: | 449.79 D |
From 38.00€
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