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Resolvin E1
Item number: Cay10007848-10
Resolvin E1 (RvE1) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) via an 18-HEPE epoxide intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA and 5-lipoxygenase...
| Keywords: | RvE1, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 552830-51-0 |
| MW: | 350.5 D |
From 207.00€
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C11 BODIPY 581/591
Item number: Cay27086-1
C11 BODIPY 581/591 is a lipid-soluble ratiometric fluorescent indicator of lipid oxidation. Upon oxidation, its excitation maximum shifts from 581 to 500 nm and the emission maximum shifts from 591 to 510 nm. C11 BODIPY 581/591 has been used in the quantitation of ferroptosis.Formal Name:...
| Keywords: | (T-4)-difluoro[5-[[5-[(1E,3E)-4-phenyl-1,3-butadien-1-yl]-2H-pyrrol-2-ylidene-kappaN]methyl]-1H-pyrrole-2-undecanoato(2-)-... |
| Application: | Lipid-soluble ratiometric fluorescent lipid oxidation indicator |
| CAS | 217075-36-0 |
| MW: | 504.4 D |
223.00€
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BCIP, p-toluidine salt
Item number: 02291.1
Soluble in DMF, hardly soluble in water. Use as alkaline phosphatase substrate forming a water insoluble blue reaction product. Often used together with NBT (Art.-Nr. 06428) for immunocytochemistry.
| Application: | Substrate for alkaline phosphatase |
| CAS | 6578-06-9 |
| MW: | 433.60 |
From 87.00€
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LY379268
Item number: Cay15351-10
LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...
| Keywords: | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Application: | mGluR2 / mGluR3 agonist |
| CAS | 191471-52-0 |
| MW: | 187.2 D |
From 75.00€
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NG,NG-dimethyl-L-Arginine (hydrochloride)
Item number: Cay80230-50
NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased...
| Keywords: | ADMA, Asymmetric dimethylarginine, N5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride |
| Application: | NOS inhibitor |
| CAS | 220805-22-1 |
| MW: | 275.2 D |
From 38.00€
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NASPM (hydrochloride)
Item number: Cay18453-25
NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward...
| Keywords: | 1-Naphthylacetyl spermine, N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide, trihydrochloride |
| Application: | AMPA receptor blocker |
| CAS | 1049731-36-3 |
| MW: | 479.9 D |
From 38.00€
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D-Luciferin (potassium salt)
Item number: Cay14681-1
D-Luciferin is a chemiluminescent substrate of firefly luciferase. It produces light upon oxidative decarboxylation by luciferase in the presence of ATP. D-Luciferin can be employed to assay the expression of the luciferase gene linked to a promoter of interest. Alternatively, D-luciferin and luciferase can be used...
| Keywords: | 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4S-thiazolecarboxylic acid, monopotassium salt |
| Application: | Chemiluminescent firefly luciferase substrate |
| CAS | 115144-35-9 |
| MW: | 318.4 D |
From 83.00€
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Cytochalasin B
Item number: Cay11328-10
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
| Keywords: | NSC 107658, Phomin,... |
| Application: | Mycotoxin |
| CAS | 14930-96-2 |
| MW: | 479.6 D |
From 73.00€
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ETC-1002
Item number: Cay26409-50
ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 µM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and...
| Keywords: | Bempedoic Acid, ESP-55016, 8-hydroxy-2,2,14,14-tetramethyl-pentadecanedioic acid |
| Application: | Prodrug |
| CAS | 738606-46-7 |
| MW: | 344.5 D |
From 49.00€
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SIN-1 (chloride)
Item number: Cay82220-10
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.Formal Name: 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride. CAS...
| Keywords: | 3-Morpholino-sydnonimine, Linsidomine, 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride |
| Application: | Peroxynitrite generation |
| CAS | 16142-27-1 |
| MW: | 206.6 D |
From 49.00€
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Staurosporine
Item number: LKT-S7600.1
A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
| Keywords: | AM-2282, STS |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
From 64.00€
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Spermine NONOate
Item number: Cay82150-10
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.Formal Name:...
| Keywords: | (Z)-1-[N-[3-aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino]diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 136587-13-8 |
| MW: | 262.4 D |
From 72.00€
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