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Palbociclib
Item number: BPS-82901-1
Palbociclib, also known as PD 0332991, is an orally active selective inhibitor of CDK4 (cyclin dependent kinase 4) and CDK6. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. It is used in the treatment of of ER (estrogen receptor) positive/HER2-negative advanced...
| Application: | Inhibition studies |
| CAS | 571190-30-2 |
From 238.00€
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Avanbulin
Item number: Cay45297-10
Avanbulin is an inhibitor of microtubule polymerization and is the active metabolite of the lysine-containing prodrug lisavanbulin. Avanbulin binds to unassembled tubulin at the binding site for colchicine (Cay9000760) and inhibits tubulin assembly (IC50 = 1.4 µM). It is cytotoxic to GBM6 and GBM9 glioblastoma cells...
| Keywords: | 3-[[4-[1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-yl]amino]-propanenitrile |
| Application: | Microtubule polymerization inhibitor, antineoplastic |
| CAS | 798577-91-0 |
| MW: | 387.4 D |
From 91.00€
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SBI-810 (hydrochloride)
Item number: Cay45322-1
SBI-810 is a beta-arrestin-2-biased positive allosteric modulator of neurotensin receptor 1 (NTS1). It increases neurotensin-1-induced beta-arrestin-2 recruitment to human NTS1 receptors in HEK293T cells (EC50 = 98 nM).2 SBI-810 (12 mg/kg) increases the paw withdrawal threshold in mouse models of postoperative,...
| Keywords: | 2-[[4-[4-(2-methoxyphenyl)-1-piperidinyl]-2-(1-methylcyclopropyl)-6-quinazolinyl]methylamino]-ethanol, dihydrochloride |
| Application: | beta-arrestin-2-biased NTS1 receptor positive allosteric modulator |
| MW: | 484.06 D |
From 55.00€
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ARC7
Item number: Cay45323-1
ARC7 is a probe for secondary metabolism in S. coelicolor. It increases the production of the polyketides germicidin A (Cay19971) and germicidin B/C in S. coelicolor.. SMILES: O=C(N1CCC(CC1)C2=NC(C3=CC=C(Cl)S3)=CS2)OC(C)(C)C. InChi Code:...
| Keywords: | 4-[4-(5-chloro-2-thienyl)-2-thiazolyl]-1-piperidinecarboxylic acid, 1-dimethylethyl ester |
| Application: | Probe for secondary metabolism in S. coelicolor |
| CAS | 681212-58-8 |
| MW: | 384.94 D |
From 105.00€
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Almonertinib
Item number: Cay45326-10
Almonertinib is an inhibitor of mutant and wild-type EGFR (IC50s = 0.18 and 2.6 nM for EGFRL858R/T790M and wild-type EGFR, respectively, in a cell-free assay). It is selective for mutant EGFRD761Y, EGFRL747S, and EGFRL861Q (IC50s = 0.84, 3.09, and 1.07 nM, respectively) over EGFR containing mutations at the G719...
| Keywords: | Aumolertinib, HS-10296,... |
| Application: | Mutant and wild-type EGFR inhibitor |
| CAS | 1899921-05-1 |
| MW: | 525.66 D |
From 222.00€
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(S)-PHA-533533
Item number: Cay45337-1
(S)-PHA-533533 is an inhibitor of cyclin-dependent kinase 2 (Cdk2)/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk1/cyclin B complexes and glycogen synthase kinase 3beta (GSK3beta, IC50s = 37, 55, 65, 208, and 732 nM, respectively, in cell-free assays). It selectively inhibits these complexes and GSK3beta over the...
| Keywords: | N-(5-cyclopropyl-1H-pyrazol-3-yl)-alphaS-methyl-4-(2-oxo-1-pyrrolidinyl)-benzeneacetamide |
| Application: | Cdk2/cyclin A inhibitor |
| CAS | 437982-89-3 |
| MW: | 338.41 D |
From 139.00€
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SR 3306
Item number: Cay45342-1
SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively). It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or...
| Keywords: | N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]-2-pyrimidinamine |
| Application: | Pan-JNK inhibitor |
| CAS | 1128096-91-2 |
| MW: | 490.57 D |
From 55.00€
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EGFR Ligand-9
Item number: Cay45392-1
EGFR ligand-9 is an EGFR ligand and a synthetic intermediate. It binds to EGFR containing the C797S mutation (EGFRC797S, (Kd = 47.9 nM), which is found in non-small cell lung cancer (NSCLC) and is associated with resistance to kinase inhibitors. EGFR ligand-9 has been used in the synthesis of proteolysis-targeting...
| Keywords: | Epidermal Growth Factor Receptor Ligand 9,... |
| Application: | EGFR ligand, synthetic intermediate |
| CAS | 2992670-44-5 |
| MW: | 530.57 D |
From 78.00€
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5-O-Caffeoylshikimic Acid
Item number: Cay45453-1
5-O-Caffeoylshikimic acid is a polyphenol originally isolated from P. aquilinum that has diverse biological activities. It inhibits xanthine oxidase (XO) in a cell-free assay (IC50 = 13.96 µM). In vivo, 5-O-caffeoylshikimic acid decreases serum uric acid, serum creatinine, and blood urea nitrogen levels, renal...
| Keywords: | 5OCSA, (3R,4R,5R)-5-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-1-cyclohexene-1-carboxylic acid |
| Application: | Bioactive polyphenol |
| CAS | 73263-62-4 |
| MW: | 336.3 D |
From 160.00€
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Melflufen (hydrochloride)
Item number: Cay45461-10
Melflufen is a prodrug form of the DNA alkylating agent melphalan (Cay16665). Melflufen induces apoptosis and inhibits growth in MM.1R, RPMI-8226, and melphalan-resistant RPMI-8226/LR5 multiple myeloma cells in a concentration-dependent manner. It induces DNA damage and inhibits VEGF-induced migration of MM.1S...
| Keywords: | J1, Melphalan Flufenamide, 4-[bis(2-chloroethyl)amino]-L-phenylalanyl-4-fluoro-L-phenylalanine, ethyl ester,... |
| Application: | Alkylating agent melphalan prodrug |
| CAS | 380449-54-7 |
| MW: | 534.88 D |
From 119.00€
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MTOB (sodium salt)
Item number: Cay45462-1
MTOB is an intermediate in the methionine salvage pathway. It is also a substrate of the dehydrogenase domain of C-terminal-binding protein 1 (CtBP1) and CtBP2 that inhibits the transcriptional corepressor activity of CtBP1 and -2 at concentrations in the millimolar range. MTOB reduces cell viability in p53...
| Keywords: | 2-Keto-5-methyl-thiobutyrate, 4-Methylthio-2-oxobutanoate, KMTB, alpha-Keto-gamma-(methylthio)butyric Acid,... |
| Application: | Methionine salvage pathway intermediate, CtBP substrate |
| CAS | 51828-97-8 |
| MW: | 170.16 D |
From 59.00€
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Enecadin
Item number: Cay45478-1
Enecadin is an inhibitor of voltage-gated sodium channels (Navs) and high-voltage activated calcium channels. It selectively inhibits Navs and L-, N-, and T-type calcium channels over voltage-gated potassium channels in NG 108-15 cells (IC50s = 7.8, 4.5, 7.3, 17.2, and 160.5 µM, respectively). In vivo, enecadin...
| Keywords: | NS-7, 4-(4-fluorophenyl)-2-methyl-6-[[5-(1-piperidinyl)pentyl]oxy]-pyrimidine |
| Application: | Navs / high-voltage activated sodium channel inhibitor |
| CAS | 259525-01-4 |
| MW: | 357.47 D |
From 230.00€
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