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RWJ 60475
Item number: Cay45483-1
RWJ 60475 is an inhibitor of CD45 (IC50 = 2 µM).. SMILES: BrC(C=C1)=CC=C1OC(C(C(P(O)(O)=O)O)=C2)=CC=C2[N+]([O-])=O. InChi Code: InChI=1S/C13H11BrNO7P/c14-8-1-4-10(5-2-8)22-12-6-3-9(15(17)18)7-11(12)13(16)23(19,20)21/h1-7,13,16H,(H2,19,20,21). InChi Key: JJKCSZKQYMYARX-UHFFFAOYSA-N
| Keywords: | P-[[2-(4-bromophenoxy)-5-nitrophenyl]hydroxymethyl]-phosphonic acid |
| Application: | CD45 inhibitor |
| CAS | 204130-08-5 |
| MW: | 404.11 D |
From 83.00€
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MNI137
Item number: Cay45486-10
MNI137 is a negative allosteric modulator of metabotropic glutamate receptor 2 (mGluR2). It selectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing human mGluR2 (IC50 = 11.4 nM) over HEK293 cells expressing rat mGluR1, -5, -7, or -8 and those expressing human mGluR4 at 10 µM.. SMILES:...
| Keywords: | 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile |
| Application: | MGluR2 negative allosteric modulator |
| CAS | 946619-21-2 |
| MW: | 341.17 D |
From 124.00€
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LCK Inhibitor II
Item number: Cay45496-1
LCK inhibitor II is an inhibitor of LCK (IC50 = 3 nM in a cell-free assay). It reduces IL-2 levels in Jurkat cells (IC50 = 54 nM). SMILES: OC1=CC=C(C)C(NC2=NC(N3C4=C(N=C3)C=CC=C4)=NC(OCCN5CCOCC5)=C2)=C1. InChi Code:...
| Keywords: | Lymphocyte-specific Protein Tyrosine Kinase II,... |
| Application: | LCK (Lymphocyte cell-specific protein-tyrosine kinase) inhibitor |
| CAS | 918870-43-6 |
| MW: | 446.51 D |
From 139.00€
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Mz325
Item number: Cay45518-1
Mz325 is a dual inhibitor of histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2, IC50s = 0.043 and 0.32 µM, respectively, in a cell-free assay). Mz325 is a heterobifunctional molecule that contains an HDAC6 inhibitor conjugated to a SIRT2 inhibitor via a triazole linker. It is selective for HDAC6 and SIRT2 over...
| Keywords: | N-butyl-4-[[3-[[2-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]-5-thiazolyl]methyl]phenoxy]methyl]-N-[[4-[(hydroxyam... |
| Application: | HDAC6 / SIRT2 dual inhibitor |
| CAS | 3032670-12-2 |
| MW: | 771.96 D |
From 55.00€
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GluN1/3A-IN-2
Item number: Cay45520-1
GluN1/3A-IN-2 is an inhibitor of NR1/3A and NR1/3B subunit-containing NMDA receptors (IC50s = 1.56 and 0.12 µM, respectively). It is selective for NR1/3A and NR1/3B subunit-containing NMDA receptors over those containing NR1/2A subunits (IC50 = >30 µM). GluN1/3A-IN-2 inhibits glycine-induced currents in a whole-cell...
| Keywords: | Compound DD-1, GluN1/3A Inhibitor 2,... |
| Application: | NR1/3A / NR1/3B subunit-containing NMDA receptor inhibitor |
| CAS | 887220-24-8 |
| MW: | 509.98 D |
From 91.00€
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2-Aminoterephthalic Acid
Item number: Cay45551-10
2-Aminoterephthalic acid is a building block that has been used as a ligand in coordination chemistry and in the synthesis of metal-organic frameworks (MOFs). SMILES: NC1=CC(C(O)=O)=CC=C1C(O)=O. InChi Code: InChI=1S/C8H7NO4/c9-6-3-4(7(10)11)1-2-5(6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13). InChi Key:...
| Keywords: | 2-ATA, 2-amino-1,4-benzenedicarboxylic acid |
| Application: | Building block |
| CAS | 10312-55-7 |
| MW: | 181.15 D |
From 35.00€
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N6,2'-O-Dimethyladenosine
Item number: Cay45570-10
N6-2'-O-Dimethyladenosine (m6Am) is a modified nucleoside, a substrate of the demethylase fat mass and obesity-associated protein (FTO), and an mRNA cap modification that increases mRNA stability. It is present on specific transcripts, including fatty acid binding protein 2 (Fabp2) and Fabp5, in an obesity-dependent...
| Keywords: | m6Am, N6,2-O-Dimethyladenosine, N-methyl-2'-O-methyl-adenosine |
| Application: | Modified nucleoside, FTO substrate |
| CAS | 57817-83-1 |
| MW: | 295.3 D |
From 139.00€
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ABT-239
Item number: Cay45575-1
ABT-239 is a histamine H3 receptor antagonist (Kis = 0.316 and 1.258 nM, respectively, for the human and rat receptors). In vivo, ABT-239 (0.1-1 mg/kg) inhibits the dipsogenic response induced by (R)-(-)-alpha-methylhistamine (Cay25601) in mice. It improves social memory in adult and aged rats and attenuates...
| Keywords: | 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzof uranyl]-benzonitrile |
| Application: | Histamine H3 receptor antagonist |
| CAS | 460746-46-7 |
| MW: | 330.43 D |
From 37.00€
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SirReal1-O-Propargyl
Item number: Cay45592-1
SirReal1-O-propargyl is an inhibitor of sirtuin 2 (SIRT2, IC50 = 2.4 µM) and a proteolysis-targeting chimera (PROTAC) building block. It is selective for SIRT2 over SIRT1 (IC50 = >100 µM). When conjugated with azido-thalidomide (Cay26146), SirReal1-O-propargyl has been used in the synthesis of a PROTAC that drives...
| Keywords: | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]-acetamide |
| Application: | SIRT2 inhibitor |
| CAS | 1862237-99-7 |
| MW: | 424.54 D |
From 83.00€
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OPB-171775
Item number: Cay45601-10
OPB-171775 is a molecular glue. It induces the formation of a complex between phosphodiesterase 3A (PDE3A) and ribonuclease SLFN12. OBI-171775 (10 nM) induces G0/G1 phase cell cycle arrest, apoptosis, and necrosis in PFSK-1 primitive neuroectodermal tumor cells, with cell cycle arrest partially blocked by the...
| Keywords: | 6-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone |
| Application: | Molecular glue |
| CAS | 2131210-15-4 |
| MW: | 312.32 D |
From 264.00€
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SMARCA-BD Ligand 1 for PROTAC (hydrochloride)
Item number: Cay45620-10
SMARCA-BD ligand 1 for PROTAC is a ligand for polybromo-1D (PBRM1), Brahma homolog (BRM), also known as SMARCA2, and Brahma-related gene 1 (BRG1), also known as SMARCA4 (Kds = 26, 135, and 73 nM, respectively). SMARCA-BD ligand 1 for PROTAC has been used in the synthesis of the proteolysis-targeting chimeras...
| Keywords: | SMARCA-BD Ligand 1 for Proteolysis-targeting Chimera, 2-[6-amino-5-(1-piperazinyl)-3-pyridazinyl]-phenol, dihydrochloride |
| Application: | PBRM1 / BRM / BRG1 ligand |
| CAS | 2369053-68-7 |
| MW: | 344.2 D |
From 244.00€
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(±)-6-epi Mesembrenol
Item number: Cay45823-1
6-epi Mesembrenol is an alkaloid that has been found in Narcissus. SMILES: COC1=C(OC)C=C(C2(CCN3C)C3([H])C[C@@H](O)C=C2)C=C1. InChi Code: InChI=1S/C17H23NO3/c1-18-9-8-17(7-6-13(19)11-16(17)18)12-4-5-14(20-2)15(10-12)21-3/h4-7,10,13,16,19H,8-9,11H2,1-3H3/t13-,16?,17?/m0/s1. InChi Key: PQBHZMSTECYZLH-IGEOTXOUSA-N
| Keywords: | (6R)-3a-(3,4-dimethoxyphenyl)-1-methyl-2,3,3a,6,7,7a-hexahydro-1H-indol-6-ol |
| Application: | Alkaloid |
| MW: | 289.38 D |
From 318.00€
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