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N-Phenyl-N'-(2-methylphenyl)-p-phenylenediamine
Item number: Cay45331-1
N-Phenyl-N'-(2-methylphenyl)-p-phenylenediamine (PTPD) is a p-phenylenediamine (PPD) and component of the tire rubber antioxidant BENPAT. It has been found in tires, road dust, and wastewater influent, effluent, biosolids, and leachate. Formulations containing PTPD have been used as stabilizers in tires, synthetic...
| Keywords: | N-o-Tolyl-N'-phenyl-p-phenylenediamine, N-Phenyl-N'-(o-tolyl)-p-phenylenediamine, PTPD,... |
| Application: | Substituted phenylenediamine, tire rubber antioxidant, toxicant, pollutant |
| CAS | 27173-16-6 |
| MW: | 274.37 D |
From 49.00€
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Narmafotinib
Item number: Cay45335-1
Narmafotinib is an inhibitor of focal adhesion kinase (FAK). It inhibits autophosphorylation of FAK at tyrosine 397 in MDA-MB-231 breast cancer cells (IC50 = 7 nM). Narmafotinib (80 mg/kg), in combination with bevacizumab, reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer. It also induces...
| Keywords: | AMP945, CTx-0294945,... |
| Application: | FAK inhibitor |
| CAS | 1393653-34-3 |
| MW: | 527.59 D |
From 78.00€
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RO5203648
Item number: Cay45362-1
RO5203648 is a partial agonist of trace amine-associated receptor 1 (TAAR1). It increases cAMP production in HEK293 cells expressing TAAR1 (EC50s = 4, 6.8, 30, and 31 nM for the mouse, rat, human, and monkey receptors, respectively). RO5203648 (500 nM) increases the firing frequency of dopaminergic and serotonergic...
| Keywords: | 4-(3,4-dichlorophenyl)-4,5-dihydro-2-oxazolamine |
| Application: | TAAR1 partial agonist |
| CAS | 1043491-54-8 |
| MW: | 231.08 D |
From 55.00€
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Dencatistat
Item number: Cay45363-1
Dencatistat is an inhibitor of CTP synthase 1 (CTPS1, IC50 = 0.0093 µM), the enzyme that catalyzes the rate-limiting step in the conversion of UTP to CTP. It is selective for CTPS1 over CTPS2 (IC50 = 12.62 µM). Dencatistat inhibits the proliferation of nine cell lines derived from T cell-based cancers (IC50s = 2-183...
| Keywords: | STP938,... |
| Application: | CTPS1 inhibitor |
| CAS | 2377000-84-3 |
| MW: | 525.58 D |
From 68.00€
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BMS 986235
Item number: Cay45369-10
BMS 986235 is a formyl peptide receptor 2 (FPR2) agonist. It selectively induces calcium mobilization in HEK293 cells overexpressing human FPR2 over FPR1 (EC50s = 0.41 and 2,800 nM, respectively). BMS 986235 inhibits chemotaxis of HL-60 human promyeloblast cells and induces phagocytosis of opsonized zymosan by...
| Keywords: | LAR-1219, N-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxo-3-pyrrolidinyl]-N'-phenyl-urea |
| Application: | FPR2 agonist |
| CAS | 2253947-47-4 |
| MW: | 361.35 D |
From 147.00€
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Dynapyrazole-A
Item number: Cay45370-10
Dynapyrazole-A is an inhibitor of the motor proteins dynein 1 and dynein 2. It inhibits the microtubule-stimulated ATPase activity of dynein but not its basal microtubule-independent activity. Dynapyrazole-A inhibits dynein 1- and dynein 2-mediated microtubule gliding in a cell-free assay (IC50s = 2.3 and 2.6 µM,...
| Keywords: | 2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo-pyrazolo[1,5-a]quinazoline-3-carbonitrile |
| Application: | Dynein 1 / dynein 2 inhibitor |
| CAS | 2226517-75-3 |
| MW: | 486.7 D |
From 105.00€
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ATR-258
Item number: Cay45371-1
ATR-258 is a GRK-biased agonist of the beta2-adrenergic receptor (beta2-AR). It binds to the orthosteric site on beta2-AR and mediates glucose uptake dependent on G protein-coupled receptor kinase 2 (GRK2) with low Galphas-dependent cAMP generation in a phenotypic screen. ATR-258 (10 µM) increases glucose uptake in...
| Keywords: | alphaR-[[(1,1-dimethylethyl)amino]methyl]-5-fluoro-3-pyridinemethanol |
| Application: | Beta2-AR GRK-biased agonist |
| CAS | 2301983-88-8 |
| MW: | 212.27 D |
From 35.00€
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(R)-STU104
Item number: Cay45375-1
(R)-STU104 is an inhibitor of the protein-protein interaction between TGF-beta-activated kinase 1 (TAK1) and MAP kinase kinase 3 (MKK3). It binds MKK3 (KD = 71 nM), inhibits the phosphorylation of MKK3 in RAW 264.7 macrophages (IC50 = 4 µM), and disrupts the interaction between MKK3 and TAK1 in the same cells....
| Keywords: | (3R)-2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-1H-inden-1-one |
| Application: | TAK1-MKK3 protein-protein interaction inhibitor |
| CAS | 2767124-77-4 |
| MW: | 298.34 D |
From 69.00€
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Plk1-IN-4
Item number: Cay45382-1
Plk1-IN-4 is an inhibitor of polo-like kinase 1 (Plk1, IC50 = 0.508 nM in a cell-free assay). It inhibits the growth of HepG2 and SMMC-7721 hepatocellular carcinoma cells (IC50s = 11.1 and 70.9 nM, respectively) and induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells. Plk1-IN-4 (30 mg/kg)...
| Keywords: | Polo-like Kinase 1 Inhibitor 4, Polo-like Kinase 1-IN-4,... |
| Application: | Plk1 inhibitor |
| CAS | 2622273-55-4 |
| MW: | 550.56 D |
From 76.00€
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PROTAC Bcl-2 Degrader-1
Item number: Cay45385-1
PROTAC Bcl-2 degrader-1 is a proteolysis-targeting chimera (PROTAC) composed of a Bcl-2 inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay19877) via a PEG linker. It induces the degradation of Bcl-2 in HeLa cells with a half-maximal degradation concentration (DC50) value of 3 µM. PROTAC Bcl-2...
| Keywords: | PROTAC BCL2 Degrader-1, Proteolysis-targeting Chimera Bcl-2 Degrader-1, Proteolysis-targeting Chimera BCL2 Degrader-1,... |
| Application: | Bcl-2 degradation driving PROTAC |
| CAS | 2378801-85-3 |
| MW: | 941.85 D |
From 485.00€
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EML4-ALK Kinase Inhibitor 1
Item number: Cay45387-1
EML4-ALK kinase inhibitor 1 is an inhibitor of the anaplastic lymphoma kinase (ALK) fusion protein EML4-ALK (IC50 = 1 nM). It inhibits the growth of Ba/F3 cells expressing EML4-ALK (IC50 = 9.7 nM). In vivo, EML4-ALK kinase inhibitor 1 (10 mg/kg) induces tumor regression in mice xenografted with NIH3T3 cells...
| Keywords: | 6-ethyl-5-[(trans-4-methoxycyclohexyl)amino]-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-2-pyr... |
| Application: | EML4-ALK inhibitor |
| CAS | 1373409-08-5 |
| MW: | 580.78 D |
From 133.00€
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TNF-alpha-IN-1
Item number: Cay45390-1
TNF-alpha-IN-1 is a glutarimide-substituted phthalimide.. SMILES: ClCC(NCC(C=CC=C1C2=O)=C1C(N2C(C(N3)=O)CCC3=O)=O)=O. InChi Code: InChI=1S/C16H14ClN3O5/c17-6-12(22)18-7-8-2-1-3-9-13(8)16(25)20(15(9)24)10-4-5-11(21)19-14(10)23/h1-3,10H,4-7H2,(H,18,22)(H,19,21,23). InChi Key: XRAYWKDMFVKUTJ-UHFFFAOYSA-N
| Keywords: | Tumor Necrosis Factor-alpha Inhibitor 1, Tumor Necrosis Factor-alpha-IN-1,... |
| Application: | Phthalimide |
| CAS | 444287-49-4 |
| MW: | 363.75 D |
From 37.00€
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