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RA839
Item number: Cay42640-1
RA839 is an inhibitor of the protein-protein interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). It binds non-covalently to the Keap1 Kelch domain (Kd = ~6 µM). RA839 increases Nrf2-dependent transcription driven by antioxidant response element...
| Keywords: | 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid |
| Application: | Keap1-Nrf2 protein-protein interaction inhibitor |
| CAS | 1832713-02-6 |
| MW: | 452.57 D |
From 35.00€
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5'-DMTr-dA(Bz)-Methyl Phosphonamidite
Item number: Cay43321-100
5'-DMTr-dA(Bz)-methyl phosphonamidite is a nuceloside building block. SMILES: CC(N(P(O[C@@H](C1)[C@H](O[C@H]1N2C=NC3=C(NC(C4=CC=CC=C4)=O)N=CN=C23)COC(C(C=C5)=CC=C5OC)(C6=CC=CC=C6)C(C=C7)=CC=C7OC)C)C(C)C)C. InChi Code:...
| Keywords: | 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite] N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'deoxy-adenosine |
| Application: | Nucleoside building block |
| CAS | 114079-05-9 |
| MW: | 802.91 D |
From 165.00€
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GEM144
Item number: Cay44647-1
GEM144 is a dual inhibitor of DNA polymerase alpha (POLA1) and histone deacetylase 11 (HDAC11). It inhibits the primer extension activity of POLA1 in a cell-free assay when used at concentrations ranging from 10 to 50 µM and increases acetylation of alpha-tubulin at lysine 40 in H460 lung cancer cells at 0.4 µM. It...
| Keywords: | (2E)-3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-2-propenoic acid |
| Application: | POLA1 / HDAC11 dual inhibitor |
| CAS | 2487526-28-1 |
| MW: | 461.56 D |
From 69.00€
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Endothall (sodium salt)
Item number: Cay44847-100
Endothall is an aquatic plant growth regulator. It reduces curly leaf pondweed appearance frequency in and dry biomass from lakes when applied annually at a concentration of 1 mg/L. Endothall reduces leaf chlorophyll content in A. thaliana plants and root length in A. thaliana seedlings (IC50s = 1.36 mM and 13.9 µM,...
| Keywords: | 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, disodium salt |
| Application: | Aquatic plant growth regulator |
| CAS | 129-67-9 |
| MW: | 230.1 D |
From 35.00€
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N-Succinimidoxycarbonyl-beta-alanine N-succinimidyl ester
Item number: Cay45144-100
N-Succinimidoxycarbonyl-beta-alanine N-succinimidyl ester is an amine-reactive homobifunctional crosslinking agent. SMILES: O=C(CC1)N(OC(CCNC(ON2C(CCC2=O)=O)=O)=O)C1=O. InChi Code: InChI=1S/C12H13N3O8/c16-7-1-2-8(17)14(7)22-11(20)5-6-13-12(21)23-15-9(18)3-4-10(15)19/h1-6H2,(H,13,21). InChi Key:...
| Keywords: | N-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-beta-alanine, 2,5-dioxo-1-pyrrolidinyl ester |
| Application: | Homobifunctional amine-reactive crosslinking agent |
| CAS | 21994-89-8 |
| MW: | 327.3 D |
From 69.00€
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2-Nitrodiphenylamine
Item number: Cay45198-10
2-Nitrodiphenylamine is a non-p-phenylenediamine (non-PPD) aromatic amine antioxidant. It has been found in soil, ground water, and marine sediment. Formulations containing 2-nitrodiphenylamine have been used as stabilizing additives in torpedo propellants and as antioxidant additives in rubber.. SMILES:...
| Keywords: | 2-nDPA, 2-nitroDPA, 2-NO2-DPA, C.I. 10335, NDPA, NSC 105613, NSC 4754, NSC 629274, 2-nitro-N-phenyl-benzenamine |
| Application: | Aromatic amine antioxidant, toxicant, pollutant |
| CAS | 119-75-5 |
| MW: | 214.22 D |
From 49.00€
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ICI 204448 (hydrochloride)
Item number: Cay45206-1
ICI 204448 is a kappa-opioid receptor agonist. It binds to the kappa-opioid receptor (Ki = 2.69 nM) and is 162- and 69-fold selective for the kappa-opioid receptor over the µ- and delta-opioid receptors in membranes prepared from cells expressing the human kappa-, µ- and delta-opioid receptors, repectively. ICI...
| Keywords: | 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]-acetic acid, monohydrochloride |
| Application: | Kappa-opioid receptor agonist |
| CAS | 121264-04-8 |
| MW: | 501.83 D |
From 39.00€
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THK5351
Item number: Cay45302-1
THK5351 is a non-radiolabeled form of 18F-THK5351, which has been used as a PET tracer for selectively imaging tau in animal models of tauopathies.. SMILES: CNC1=NC=C(C=C1)C2=NC(C=CC(OC[C@@H](CF)O)=C3)=C3C=C2. InChi Code:...
| Keywords: | 1-fluoro-3-[[2-[6-(methylamino)-3-pyridinyl]-6-quinolinyl]oxy]-2S-propanol |
| Application: | 18F-THK5351 non-radiolabeled form, tau/MAO-B binding |
| CAS | 1707147-26-9 |
| MW: | 327.36 D |
From 244.00€
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GSK3beta Inhibitor XIII
Item number: Cay45310-1
GSK3beta inhibitor XIII is an inhibitor of glycogen synthase kinase beta (GSK3beta, IC50 = 0.73 nM). It is selective for GSK3beta over cyclin-dependent kinase 2 (Cdk2), Cdk5, AP2-associated protein kinase 1 (AAK1), Pim-1, and PKCtheta (IC50s = 1.4, 6.4, 0.2, 0.38, and 0.36 µM, respectively) and a panel of 30...
| Keywords: | Glycogen Synthase Kinase beta Inhibitor 13, Glycogen Synthase Kinase beta Inhibitor XIII, GSK3beta Inhibitor 13,... |
| Application: | GSK3beta inhibitor |
| CAS | 2227316-74-5 |
| MW: | 414.47 D |
From 139.00€
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GSK690 (hydrochloride)
Item number: Cay45320-1
GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). GSK690 potentiates reductions in viability of SJCRH30...
| Keywords: | 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-benzonitrile, monohydrochloride |
| Application: | Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibitor |
| CAS | 2436760-79-9 |
| MW: | 405.93 D |
From 69.00€
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ARD-266
Item number: Cay45321-1
ARD-266 is a proteolysis-targeting chimera (PROTAC) containing an androgen receptor antagonist conjugated to a VHL ligand via a piperidine-alkyne linker. It induces degradation of the androgen receptor in LNCaP, VCaP, and 22Rv1 prostate cancer cells with half-maximal degradation concentration (DC50) values of 0.54,...
| Keywords: | (2S,4R)-N-[(1S)-3-[4-[2-[4-[[[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]ethyny... |
| Application: | Androgen receptor (AR/NR3C4) degradation driving PROTAC |
| CAS | 2666951-70-6 |
| MW: | 915.53 D |
From 139.00€
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N-Phenyl-N'-(2-methylphenyl)-p-phenylenediamine
Item number: Cay45331-1
N-Phenyl-N'-(2-methylphenyl)-p-phenylenediamine (PTPD) is a p-phenylenediamine (PPD) and component of the tire rubber antioxidant BENPAT. It has been found in tires, road dust, and wastewater influent, effluent, biosolids, and leachate. Formulations containing PTPD have been used as stabilizers in tires, synthetic...
| Keywords: | N-o-Tolyl-N'-phenyl-p-phenylenediamine, N-Phenyl-N'-(o-tolyl)-p-phenylenediamine, PTPD,... |
| Application: | Substituted phenylenediamine, tire rubber antioxidant, toxicant, pollutant |
| CAS | 27173-16-6 |
| MW: | 274.37 D |
From 49.00€
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