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GYY 4137
Item number: Cay13345-100
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the...
| Keywords: | (p-methoxyphenyl)morpholino-phosphinodithioic acid |
| Application: | Hydrogen sulfide donor |
| CAS | 106740-09-4 |
| MW: | 377.5 D |
From 95.00€
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Brevetoxin B
Item number: Cay10011498-100
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal,...
| Keywords: | Brevetoxin PbTx 2, GB-2 Toxin, Ptychodiscus brevis toxin 2, T-34 Toxin,... |
| Application: | Polyketide neurotoxin |
| CAS | 79580-28-2 |
| MW: | 895.1 D |
971.00€
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Latrunculin B
Item number: AG-CN2-0031-M001
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Less potent than Latrunculin A. May have fewer unwanted effects than latrunculin A and may be...
| Keywords: | LAT-B, NSC 339663 |
| Application: | Actin polymerization inhibitor |
| CAS | 76343-94-7 |
| MW: | 395,5 D |
From 154.00€
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5-Azacytidine
Item number: Cay11164-50
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 µM for in vitro anti-myeloma...
| Keywords: | 5-AzaC, Antibiotic U 18496, Ladakamycin, Mylosar, NSC 102816, NSC 103-627, U 18496, WR 183027,... |
| Application: | DNA methyltransferase inhibitor |
| CAS | 320-67-2 |
| MW: | 244.2 D |
From 45.00€
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Triacsin C
Item number: Cay10007448-500
Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 µM in Raji cells). It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters. It is also known to act as a...
| Keywords: | FR 900190, WS 1228A, 2E,4E,7E-undecatrienal, nitrosohydrazone |
| Application: | Long fatty acid acyl-CoA synthetase inhibitor |
| CAS | 76896-80-5 |
| MW: | 207.3 D |
From 458.00€
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SNAP
Item number: Cay82250-10
SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content. At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion...
| Keywords: | S-Nitroso-N-Acetyl-D,L-Penicillamine, N-(acetyloxy)-3-nitrosothiovaline |
| Application: | NO donor |
| CAS | 67776-06-1 |
| MW: | 220.2 D |
From 60.00€
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Cl-Amidine (hydrochloride)
Item number: Cay10599-1
Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs, IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively). It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 µM, respectively). Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil...
| Keywords: | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride |
| Application: | Peptidyl arginine deiminase (PAD) inhibitor |
| CAS | 1373232-26-8 |
| MW: | 347.2 D |
From 76.00€
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all-trans Retinoic Acid
Item number: Cay11017-50
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...
| Keywords: | atRA, NSC 122578, NSC 122758, RA, Vitamin A Acid,... |
| Application: | RAR / RXR ligand |
| CAS | 302-79-4 |
| MW: | 300.4 D |
From 57.00€
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25-hydroxy Vitamin D3
Item number: Cay9000683-1
Deficiency of vitamin D leads to abnormal calcium and phosphorus metabolism, contributing to deficiencies in bone formation, neuromuscular function, and inflammatory response. 25-hydroxy Vitamin D3 is an intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3, the most receptor-active form...
| Keywords: | 25-hydroxy Cholecalciferol, RO 8-8892, Rovimix Hy-D, U 32070E,... |
| Application: | Vitamin D Ligand |
| CAS | 19356-17-3 |
| MW: | 400.6 D |
From 132.00€
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TCEP (hydrochloride)
Item number: Cay14329-1
TCEP is an odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications. It is commonly used to rapidly reduce protein and peptide disulfide bonds. TCEP can be combined with proteases to simultaneously reduce and digest proteins prior to mass spectrometry in order to...
| Keywords: | Tris(2-carboxyethyl)phosphine, 3,3',3''-phosphinylidynetris-propanoic acid, monohydrochloride |
| Application: | Water-soluble reducing agent |
| CAS | 51805-45-9 |
| MW: | 286.7 D |
69.00€
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NO-Pravastatin
Item number: Cay10006044-1
NO-pravastatin is a derivative of pravastatin (Cay10010343) that contains a nitric oxide-releasing moiety. It induces cGMP formation in PC12 cells (EC50 = 2.3 µM) and inhibits the proliferation of isolated rat aortic smooth muscle cells (IC50 = 2.2 µM). NO-pravastatin reduces inducible nitric oxide synthase (iNOS)...
| Keywords: | NCX 6550,... |
| Application: | Nitric oxide-releasing moiety containing pravastatin derivative, HMG-CoA reductase inhibitor |
| CAS | 733034-46-3 |
| MW: | 541.64 D |
From 35.00€
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PF-03882845
Item number: Cay10669-1
PF-03882845 is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 26 nM). It is selective for the mineralocorticoid receptor over the androgen, glucocorticoid, and progesterone receptors in reporter assays using Huh7 cells (IC50s = >10,000, >10,000, and 1,880 nM, respectively). PF-03882845 (40 and 100...
| Keywords: | 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3S,3aR,4,5-tetrahydro-2H-benz[g]indazole-7-carboxylic acid |
| Application: | Non-steroidal mineralocorticoid receptor antagonist |
| CAS | 1023650-66-9 |
| MW: | 419.9 D |
From 42.00€
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