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Bafilomycin A1 (solution)
Item number: Cay46024-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Keywords: | NSC 381866,... |
| Application: | Bioactive bacterial metabolite |
| CAS | 88899-55-2 |
| MW: | 622.84 D |
From 248.00€
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HC-5404
Item number: Cay45588-1
HC-5404 is an inhibitor of protein kinase R-like ER kinase (PERK, IC50 = 4 nM in a cell-free assay). It is selective for PERK over a panel of 25 kinases at 1 mM. HC-5404 reduces the levels of phosphorylated eukaryotic translation initiation factor 2alpha subunit (eIF2alpha) in HEK293 cells (IC50 = 33 nM). It reduces...
| Keywords: | LY-4,... |
| Application: | PERK (EIF2AK3) inhibitor |
| CAS | 2247396-91-2 |
| MW: | 454.48 D |
From 69.00€
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Spiraeoside
Item number: Cay45667-1
Spiraeoside is a flavonoid glycoside that has been found in F. ulmaria and has diverse biological activities. It scavenges DPPH (Cay14805) and hydroxyl radicals (IC50s = 19.54 and 5.1 µg/ml, respectively) and inhibits beta-glucuronidase and lipoxygenase (LO) in cell-free assays. Spiraeoside (15 µg/ml) induces cell...
| Keywords: | Quercetin 4'-O-glucoside, Quercetin-4-O-beta-D-glycoside,... |
| Application: | Bioactive flavonoid glycoside |
| CAS | 20229-56-5 |
| MW: | 464.38 D |
From 91.00€
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2-(1-(3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)-5-fluoro-...
Item number: Cay45721-10
2-(1-(3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)-5-fluoro-1-methyl-1H-indazol-6-yl)-4-hydroxypiperidin-4-yl)acetic acid is a proteolysis-targeting chimera (PROTAC) building block. It has been used in the synthesis of a PROTAC that drives mutant B-RAF degradation.. SMILES:...
| Keywords: | 1-[5-fluoro-1-methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-1H-indazol-6-yl]-4-hydroxy-4-piperidineacetic acid |
| Application: | PROTAC building block |
| CAS | 2654826-81-8 |
| MW: | 419.41 D |
From 83.00€
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Phalloidin-iFluor(TM) 488 Conjugate
Item number: Cay20549-300
Phalloidin-iFluor(TM) 488 Conjugate is a fluorescein-based dye used to label actin filaments (F-actin). Phalloidin binds to F-actin and prevents depolymerization. It also inhibits the ATP hydrolysis action of F-actin. Phalloidin-iFluor(TM) 488 can be used to label tissue, cells, and cell-free preparations that have...
| Application: | Fluorescence, ICC, IF, IHC |
345.00€
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PPACK (trifluoroacetate salt)
Item number: Cay15160-10
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM). It has been used as an anticoagulant (100 µM) and to study thrombin-mediated fibrin deposition, angiogenesis, and...
| Keywords: | D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, Pebac,... |
| Application: | Thrombin inhibitor |
| MW: | 451 D |
From 58.00€
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Cytarabine
Item number: Cay16069-10
Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human...
| Keywords: | 1-beta-D-Arabinofuranosylcytosine, NSC 287459, NSC 63878, U-19920A, 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone |
| Application: | Competitive DNA polymerase inhibitor |
| CAS | 147-94-4 |
| MW: | 243.2 D |
From 76.00€
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DL-threo-PPMP (hydrochloride)
Item number: Cay17236-5
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin...
| Keywords: | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol,... |
| Application: | Glucosylceramide synthase inhibitor |
| CAS | 139974-41-7 |
| MW: | 511.2 D |
From 62.00€
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Liproxstatin-1
Item number: Cay17730-5
Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...
| Keywords: | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
| Application: | Ferroptosis inhibitor |
| CAS | 950455-15-9 |
| MW: | 340.9 D |
From 97.00€
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Coelenterazine h *UltraPure grade*
Item number: ABD-21159
Calcium measurement is critical for numerous biological investigations. The aequorin complex comprises a 22 kD apoaequorin protein, molecular oxygen and the luminophore coelenterazine.
| Application: | Calcium indicator |
| CAS | 50909-86-9 |
From 114.00€
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Y-27632 . dihydrochloride
Item number: AG-CR1-3564-M010
Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks...
| Keywords: | Y-27632 - 2HCL, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride |
| Application: | ROCK kinase inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.2 D |
From 55.00€
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Sulfosuccinimidyl Oleate (sodium salt)
Item number: Cay11211-5
Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin...
| Keywords: | SSO, 1-(oleoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid, monosodium salt |
| Application: | Irreversible fatty acid translocase CD36 inhibitor |
| CAS | 1212012-37-7 |
| MW: | 482.6 D |
From 120.00€
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