No results were found for the filter!
Glenthmycin L
Item number: Cay45513-1
Glenthmycin L is a macrocyclic spirotetronate originally isolated from Streptomyces that has antibacterial activity. It is active against S. aureus, methicillin-resistant S. aureus (MRSA), and E. faecalis (IC50s = 1.2, 0.9, and 3.7 µM, respectively).. SMILES:...
| Keywords: | (1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,19E,20aS,20bR)-21-hydroxy-1,6,7,11,14,15,20a-heptamethyl-18,20-dioxo-1,2,3,4,4a,6a,9,1... |
| Application: | Macrocyclic spirotetronate, antibacterial agent |
| CAS | 3040055-91-9 |
| MW: | 562.75 D |
From 249.00€
*
Liraglutide
Item number: Cay45521-1
Liraglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) and a synthetic derivative of GLP-1 (7-37, Item No. 24887). It increases cAMP accumulation in BHK cells expressing GLP-1R (EC50 = 61 pM). Liraglutide (100-1,000 nM) inhibits cytokine- and free fatty acid-induced apoptosis of primary neonatal...
| Keywords: | NN 2211, NNC 90-1170, L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenyla... |
| Application: | GLP-1R agonist |
| CAS | 204656-20-2 |
| MW: | 3751.26 D |
From 47.00€
*
Bisphenol S
Item number: Cay45556-1
Bisphenol S (BPS) is a derivative of bisphenol A (BPA), an environmental contaminant, and an endocrine disruptor. It has been detected in surface water and sewage effluent and in personal care products, paper, and food. BPS increases estrogenic activity in vitro, in female rats, and in male and female zebrafish. It...
| Keywords: | 4,4'-Sulfonyldiphenol, Bis(4-hydroxyphenyl)sulfone, BPS, NSC 683541, NSC 8712, 4,4'-sulfonylbis-phenol |
| Application: | BPA derivative, environmental contaminant, endocrine disruptor |
| CAS | 80-09-1 |
| MW: | 250.27 D |
From 35.00€
*
Bisphenol F
Item number: Cay45557-10
Bisphenol F (BPF) is a derivative of bisphenol A (BPA), an environmental contaminant, and an endocrine disruptor. It has been detected in personal care products, wastewater treatment sludge, bottled water, and canned foods. BPF has estrogenic activity in vitro and in female rats. It also has neurotoxic effects,...
| Keywords: | 4,4'-Dihydroxydiphenylmethane, BPF, NSC 401136, 4,4'-methylenebis-phenol |
| Application: | BPA derivative |
| CAS | 620-92-8 |
| MW: | 200.24 D |
From 119.00€
*
Progabide
Item number: Cay45568-10
Progabide is a GABA receptor agonist. It selectively binds to the GABAA and GABAB receptors in postmortem rat cortical membranes (IC50s = 35 and 100 µM, respectively) over alpha- and beta-adrenergic, dopamine, serotonin, histamine H1, and muscarinic receptors (IC50s = >100 µM) in radioligand binding assays....
| Keywords: | SL 76002, 4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]-butanamide |
| Application: | GABA receptor agonist |
| CAS | 62666-20-0 |
| MW: | 334.78 D |
From 64.00€
*
Bunazosin (hydrochloride)
Item number: Cay45574-10
Bunazosin is an antagonist of the alpha1-adrenergic receptor (alpha1-AR, Kd = 0.59 nM). It reduces glutamate-induced decreases in viability in primary rat retinal cells when used at concentrations of 1 and 10 µM. Ocular instillation of bunazosin (0.01%) prevents phenylephrine- or endothelin-1-induced constriction of...
| Keywords: | DDQ, E-643, 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1H-1,4-diazepin-1-yl]-1-butanone, monohydrochloride |
| Application: | Alpha1-AR antagonist |
| CAS | 52712-76-2 |
| MW: | 409.92 D |
From 124.00€
*
Dabuzalgron (hydrochloride)
Item number: Cay45580-10
Dabuzalgron is a partial agonist of the alpha1A-adrenergic receptor (alpha1A-AR). It selectively binds to alpha1A-ARs over alpha1B- and alpha1D-ARs in CHO-K1 cells expressing the recombinant human receptors (Kis = 0.041, 1.6, and 6.5 µM, respectively) and selectively induces inositol phosphate accumulation in...
| Keywords: | Ro 115-1240, N-[6-chloro-3-[(4,5-dihydro-1H-imidazol-2-yl)methoxy]-2-methylphenyl]-methanesulfonamide, monohydrochloride |
| Application: | Alpha1A-AR partial agonist |
| CAS | 219311-43-0 |
| MW: | 354.25 D |
From 208.00€
*
3BrB-PP1
Item number: Cay45582-10
3BrB-PP1 is a bumped kinase inhibitor (BKI) that acts as a selective, ATP-competitive inhibitor of kinases with gatekeeper mutations. It increases the activity of the T. gondii bradyzoite-specific BAG1 promoter. 3BrB-PP1 has been used to study kinase activity using kinases containing mutations at gatekeeper residues...
| Keywords: | 3-[(3-bromophenyl)methyl]1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Application: | Bumped kinase inhibitor |
| CAS | 956025-99-3 |
| MW: | 360.26 D |
From 235.00€
*
6,6'-Oxybis(2-naphthalenesulfonate) (sodium salt)
Item number: Cay45595-1
6,6'-Oxybis(2-naphthalenesulfonate) is a byproduct in the synthesis of FD&C Yellow No. 6 and FD&C Red No. 40 (Allura Red AC, Item No. 44514). It is formed during the synthesis of Schaeffer's salt, an intermediate used in the synthesis of FD&C Yellow No. 6. 6,6'-Oxybis(2-naphthalenesulfonate) is also an impurity...
| Keywords: | DONS, 6,6'-oxybis-2-naphthalenesulfonic acid, disodium salt |
| Application: | Food dye synthesis byproduct |
| CAS | 61551-82-4 |
| MW: | 474.4 D |
From 153.00€
*
E3 Ligase Ligand 18
Item number: Cay45600-10
E3 ligase ligand 18 is a substituted purine derivative.. SMILES: NC(NC1=C2N=C(N1CC3=CC=C(Cl)C=C3)SC[C@H](NC(C)=O)C(O)=O)=NC2=O. InChi Code: InChI=1S/C17H17ClN6O4S/c1-8(25)20-11(15(27)28)7-29-17-21-12-13(22-16(19)23-14(12)26)24(17)6-9-2-4-10(18)5-3-9/h2-5,11H,6-7H2,1H3,(H,20,25)(H,27,28)(H3,19,22,23,26)/t11-/m0/s1....
| Keywords: | N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-L-cysteine |
| Application: | Substituted purine derivative |
| CAS | 2241669-88-3 |
| MW: | 436.87 D |
From 139.00€
*
HD-TAC7
Item number: Cay45613-1
HD-TAC7 is a proteolysis-targeting chimera (PROTAC) composed of a class I histone deacetylase (HDAC) inhibitor linked to the cereblon ligand pomalidomide (Cay19877). It binds to HDAC1, HDAC2, and HDAC3 (IC50s = 3.6, 4.2, and 1.1 µM, respectively) and induces degradation of HDAC3 in RAW 264.7 cells with a...
| Keywords: | N-(2-amino-4-fluorophenyl)-4-[[5-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]-am... |
| Application: | HDAC3 degradation driving PROTAC |
| CAS | 2978763-95-8 |
| MW: | 657.66 D |
From 278.00€
*
SKLB03220
Item number: Cay45614-1
SKLB03220 is a covalent inhibitor of the histone-lysine methyltransferase enhancer of zeste homolog 2 (EZH2, IC50 = 1.72 nM). It also inhibits EZH2A677G, EZH2Y641N, and EZH2Y641F, mutations found in various cancers, when used at a concentration of 10 nM. SKLB03220 is selective for EZH2 over a variety of other...
| Keywords: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2',4-dimethyl-5'-[(1-oxo-2... |
| Application: | Covalent EZH2 inhibitor |
| CAS | 2852050-29-2 |
| MW: | 556.71 D |
From 35.00€
*