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Lumateperone
Item number: Cay45296-100
Lumateperone is an atypical antipsychotic. It selectively binds to the serotonin (5-HT) receptor subtype 5-HT2A over 5-HT1A and 5-HT2C receptors (Kis = 0.54, 1,480, and 173 nM, respectively). Lumateperone also binds to dopamine D1, D2, and D4 receptors (Kis = 52, 32, and 108 nM, respectively), alpha1A- and...
| Keywords: | ITI-007, ITI-722,... |
| Application: | Atypical antipsychotic |
| CAS | 313368-91-1 |
| MW: | 393.51 D |
From 64.00€
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GSK690
Item number: Cay45336-10
GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). It potentiates reductions in viability of SJCRH30...
| Keywords: | 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-benzonitrile |
| Application: | LSD1 inhibitor |
| CAS | 2101305-84-2 |
| MW: | 369.47 D |
From 97.00€
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Alternaric Acid
Item number: Cay45460-1
Alternaric acid is a phytotoxin that has been found in A. solani. It inhibits germination and root development of carrot, mustard, radish, and tomato seeds when used at a concentration of 5 µg/ml and induces necrotic lesions in potato shoots. Alternaric acid (0.005-100 µg/ml) is also active against several plant...
| Keywords: | 4,5-dideoxy-2-C-[(1E)-7-[(6R)-5,6-dihydro-4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl]-4-methylene-7-oxo-1... |
| Application: | Phytotoxin |
| CAS | 10088-62-7 |
| MW: | 410.46 D |
From 319.00€
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Shearinine A
Item number: Cay45475-1
Shearinine A is an indole diterpene that has been found in P. janthinellum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B), T cell protein tyrosine phosphatase (TCPTP), Src homology region 2 domain-containing phosphatase 1 (SHP-1), and SHP-2 (IC50s = 1.3, 3.8, 2.9, and 4...
| Keywords: | (+)-Shearinine A,... |
| Application: | Bioactive indole diterpene fungal metabolite |
| CAS | 163136-24-1 |
| MW: | 583.77 D |
From 235.00€
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MMP Inhibitor III
Item number: Cay45494-1
MMP inhibitor III is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs, IC50s = 4.1, 3.6, 8.2, and 6.4 nM for MMP-1, MMP-2, MMP-12, and MMP-13, respectively). It also inhibits MMP-3 with an IC50 value of 134 nM. MMP inhibitor III reduces ionomycin-induced shedding of CD146 in human microvascular lung...
| Keywords: | Matrix Metalloproteinase Inhibitor III,... |
| Application: | Broad-spectrum MMP inhibitor |
| CAS | 927827-98-3 |
| MW: | 363.46 D |
From 245.00€
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Geministatin D
Item number: Cay45510-100
Geministatin D is a degradation product of the fungal metabolite geministatin A. It is active against B. subtilis and S. cerevisiae (MICs = 25 and 13 µg/ml, respectively).. SMILES: OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC(CCCCCCC/C=C\C/C=C\CCCCC)=C(C(O)=O)C(O)=C2)O1. InChi Code:...
| Keywords: | 2-(-heptadeca-8Z,11Z-dien-1-yl)-6-hydroxy-4-(((2S)-3R,4S,5R-trihydroxy-6R-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benz... |
| Application: | Geministatin A degradation product |
| MW: | 550.69 D |
From 191.00€
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Glenthmycin J
Item number: Cay45512-1
Glenthmycin J is a macrocyclic spirotetronate originally isolated from Streptomyces.. SMILES: OC([C@@]12[C@@](/C=C(CC/C=C([C@@]3([H])[C@@]4([C@@]5([H])[C@]([C@H](CC[C@@H]5C)O)([H])C=C3C)C)\C)\C)([H])C=C([C@@H](C1)C)C)=C(C(O2)=O)C4=O. InChi Code:...
| Keywords: | (1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,19E,20aS,20bR)-4,21-dihydroxy-1,6,7,11,14,15,20a-heptamethyl-2,3,4,4a,6a,9,10,12a,15,1... |
| Application: | Macrocyclic spirotetronate |
| CAS | 3040055-89-5 |
| MW: | 520.71 D |
From 355.00€
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Glenthmycin L
Item number: Cay45513-1
Glenthmycin L is a macrocyclic spirotetronate originally isolated from Streptomyces that has antibacterial activity. It is active against S. aureus, methicillin-resistant S. aureus (MRSA), and E. faecalis (IC50s = 1.2, 0.9, and 3.7 µM, respectively).. SMILES:...
| Keywords: | (1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,19E,20aS,20bR)-21-hydroxy-1,6,7,11,14,15,20a-heptamethyl-18,20-dioxo-1,2,3,4,4a,6a,9,1... |
| Application: | Macrocyclic spirotetronate, antibacterial agent |
| CAS | 3040055-91-9 |
| MW: | 562.75 D |
From 249.00€
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Liraglutide
Item number: Cay45521-1
Liraglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) and a synthetic derivative of GLP-1 (7-37, Item No. 24887). It increases cAMP accumulation in BHK cells expressing GLP-1R (EC50 = 61 pM). Liraglutide (100-1,000 nM) inhibits cytokine- and free fatty acid-induced apoptosis of primary neonatal...
| Keywords: | NN 2211, NNC 90-1170, L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenyla... |
| Application: | GLP-1R agonist |
| CAS | 204656-20-2 |
| MW: | 3751.26 D |
From 47.00€
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Bisphenol F
Item number: Cay45557-10
Bisphenol F (BPF) is a derivative of bisphenol A (BPA), an environmental contaminant, and an endocrine disruptor. It has been detected in personal care products, wastewater treatment sludge, bottled water, and canned foods. BPF has estrogenic activity in vitro and in female rats. It also has neurotoxic effects,...
| Keywords: | 4,4'-Dihydroxydiphenylmethane, BPF, NSC 401136, 4,4'-methylenebis-phenol |
| Application: | BPA derivative |
| CAS | 620-92-8 |
| MW: | 200.24 D |
From 119.00€
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3BrB-PP1
Item number: Cay45582-10
3BrB-PP1 is a bumped kinase inhibitor (BKI) that acts as a selective, ATP-competitive inhibitor of kinases with gatekeeper mutations. It increases the activity of the T. gondii bradyzoite-specific BAG1 promoter. 3BrB-PP1 has been used to study kinase activity using kinases containing mutations at gatekeeper residues...
| Keywords: | 3-[(3-bromophenyl)methyl]1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Application: | Bumped kinase inhibitor |
| CAS | 956025-99-3 |
| MW: | 360.26 D |
From 235.00€
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6,6'-Oxybis(2-naphthalenesulfonate) (sodium salt)
Item number: Cay45595-1
6,6'-Oxybis(2-naphthalenesulfonate) is a byproduct in the synthesis of FD&C Yellow No. 6 and FD&C Red No. 40 (Allura Red AC, Item No. 44514). It is formed during the synthesis of Schaeffer's salt, an intermediate used in the synthesis of FD&C Yellow No. 6. 6,6'-Oxybis(2-naphthalenesulfonate) is also an impurity...
| Keywords: | DONS, 6,6'-oxybis-2-naphthalenesulfonic acid, disodium salt |
| Application: | Food dye synthesis byproduct |
| CAS | 61551-82-4 |
| MW: | 474.4 D |
From 153.00€
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