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PPACK (trifluoroacetate salt)
Item number: Cay15160-10
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM). It has been used as an anticoagulant (100 µM) and to study thrombin-mediated fibrin deposition, angiogenesis, and...
| Keywords: | D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, Pebac,... |
| Application: | Thrombin inhibitor |
| MW: | 451 D |
From 58.00€
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Cytarabine
Item number: Cay16069-10
Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human...
| Keywords: | 1-beta-D-Arabinofuranosylcytosine, NSC 287459, NSC 63878, U-19920A, 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone |
| Application: | Competitive DNA polymerase inhibitor |
| CAS | 147-94-4 |
| MW: | 243.2 D |
From 76.00€
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DL-threo-PPMP (hydrochloride)
Item number: Cay17236-5
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin...
| Keywords: | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol,... |
| Application: | Glucosylceramide synthase inhibitor |
| CAS | 139974-41-7 |
| MW: | 511.2 D |
From 62.00€
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Thapsigargin (high purity)
Item number: AG-CN2-0003-M001
Colorless to white amorphous powder. Soluble in DMSO or 100% ethanol. Chemical. CAS: 67526-95-8. Formula: C34H50O12. MW: 650.8. Isolated from Thapsia garganica. Intracellular Ca2+ signaling probe. Specific and sensitive inhibitor of SERCA. Non-TPA/PMA tumor promoter. Histamine release inducer. Apoptosis inducer....
| Application: | SERCA inhibitor, Ca2+ releaser |
| CAS | 67526-95-8 |
| MW: | 650,8 D |
From 55.00€
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Liproxstatin-1
Item number: Cay17730-5
Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...
| Keywords: | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
| Application: | Ferroptosis inhibitor |
| CAS | 950455-15-9 |
| MW: | 340.9 D |
From 97.00€
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Coelenterazine h *UltraPure grade*
Item number: ABD-21159
Calcium measurement is critical for numerous biological investigations. The aequorin complex comprises a 22 kD apoaequorin protein, molecular oxygen and the luminophore coelenterazine.
| Application: | Calcium indicator |
| CAS | 50909-86-9 |
From 114.00€
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Y-27632 . dihydrochloride
Item number: AG-CR1-3564-M010
Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks...
| Keywords: | Y-27632 - 2HCL, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride |
| Application: | ROCK kinase inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.2 D |
From 55.00€
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Sulfosuccinimidyl Oleate (sodium salt)
Item number: Cay11211-5
Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin...
| Keywords: | SSO, 1-(oleoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid, monosodium salt |
| Application: | Irreversible fatty acid translocase CD36 inhibitor |
| CAS | 1212012-37-7 |
| MW: | 482.6 D |
From 120.00€
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S-(5'-Adenosyl)-L-methionine (tosylate)
Item number: Cay16376-50
S-(5'-Adenosyl)-L-methionine (SAM) is a methyl donor and cofactor. It is involved in several biological processes, including epigenetic regulation, post-translational modification of proteins, and metabolism. Formulations containing SAM have been used as dietary supplements.Formal Name:...
| Keywords: | SAMe, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine, 4-methylbenzenesulfonate |
| Application: | Methyl donor, cosubstrate |
| CAS | 52248-03-0 |
| MW: | 570.6 D |
From 126.00€
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DPTA NONOate
Item number: Cay82110-10
DPTA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
| Keywords: | Dipropylenetriamine NONOate, (Z)-1-[N-(3-aminopropyl)-N-(3-ammoniopropyl)amino]diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 146724-95-0 |
| MW: | 191.2 D |
From 70.00€
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GYY 4137
Item number: Cay13345-100
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the...
| Keywords: | (p-methoxyphenyl)morpholino-phosphinodithioic acid |
| Application: | Hydrogen sulfide donor |
| CAS | 106740-09-4 |
| MW: | 377.5 D |
From 95.00€
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Crotamiton
Item number: Cay23943-5
N-Ethyl-o-Crotonotoluidide, N-ethyl-N-(2-methylphenyl)-2-butenamide
| Keywords: | N-Ethyl-o-Crotonotoluidide, N-ethyl-N-(2-methylphenyl)-2-butenamide |
| Application: | Antipruritic |
| CAS | 483-63-6 |
| MW: | 203.3 D |
From 314.00€
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