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(-)-Blebbistatin
Item number: Cay13013-5
(-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases and the active enantiomer of (+)-blebbistatin (Cay-13165). It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly...
| Keywords: | (S)-Blebbistatin, 1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one |
| Application: | Non-muscle myosin II ATPase inhibitor |
| CAS | 856925-71-8 |
| MW: | 292.3 D |
From 101.00€
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SB203580
Item number: AG-CR1-0030-M001
Cell permeable, specific p38 MAP kinase inhibitor, Binds to the ATP binding site of p38 MAP kinase, T cell proliferation inhibitor, IL-2 production inhibitor, SAPK/JNK inhibitor, COX-1 and -2 inhibitor, Raf-1 activator, Apoptosis enhancer, Antiproliferative, PDK1 inhibitor, Anti-inflammatory, Review.
| Keywords: | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| Application: | p38 MAP kinase inhibitor |
| CAS | 152121-47-6 |
| MW: | 377,4 D |
From 39.00€
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Etoposide
Item number: Cay12092-25
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...
| Keywords: | EPE, NSC 141540, VP-16-123,... |
| Application: | DNA Topoisomerase II inhibitor, Apoptosis inducer |
| CAS | 33419-42-0 |
| MW: | 588.6 D |
From 40.00€
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Paclitaxel
Item number: AG-CN2-0045-M005
Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase....
| Keywords: | Taxol, BMS 181339-01, NSC 125973 |
| Application: | Apoptosis Inducer |
| Host: | Taxus brevifolia |
| CAS | 33069-62-4 |
| MW: | 853,9 D |
From 22.00€
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3-Methyladenine
Item number: Cay13242-25
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....
| Keywords: | 3-MA, NSC 66389, 3-methyl-3H-purin-6-amine |
| Application: | PI3K inhibitor |
| CAS | 5142-23-4 |
| MW: | 149.2 D |
From 53.00€
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IBMX
Item number: Cay13347-100
IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 µM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP...
| Keywords: | 1-Methyl-3-Isobutylxanthine, Isobutylmethylxanthine, NSC 165960, SC-2964,... |
| Application: | PDE inhibitor |
| CAS | 28822-58-4 |
| MW: | 222.3 D |
From 60.00€
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Brevetoxin B
Item number: Cay10011498-100
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal,...
| Keywords: | Brevetoxin PbTx 2, GB-2 Toxin, Ptychodiscus brevis toxin 2, T-34 Toxin,... |
| Application: | Polyketide neurotoxin |
| CAS | 79580-28-2 |
| MW: | 895.1 D |
971.00€
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Olaparib
Item number: Cay10621-5
Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
| Keywords: | AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Application: | PARP1 / PARP2 inhibitor |
| CAS | 763113-22-0 |
| MW: | 434.5 D |
From 70.00€
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Camptothecin
Item number: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Keywords: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Application: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
From 42.00€
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(+)-Biotin 4-Amidobenzoic Acid (sodium salt)
Item number: Cay20534-50
(+)-Biotin 4-amidobenzoic acid is a biotinidase substrate. Upon enzymatic hydrolysis, 4-aminobenzoic acid (PABA, Cay-18659) is released which can be quantified by colorimetric detection at 540 nm in the presence of N-1-naphthylethylenediamine as a measure of biotinidase activity. (+)-Biotin 4-amidobenzoic acid has...
| Keywords: | (+)-Biotin PABA, 4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-benzoic acid,... |
| Application: | Biotinidase substrate |
| CAS | 102418-74-6 |
| MW: | 385.4 D |
From 51.00€
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Inflachromene
Item number: Cay17006-10
Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also...
| Keywords: | ICM, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione |
| Application: | Microglial inhibitor |
| CAS | 908568-01-4 |
| MW: | 377.4 D |
From 205.00€
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PF-03882845
Item number: Cay10669-1
PF-03882845 is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 26 nM). It is selective for the mineralocorticoid receptor over the androgen, glucocorticoid, and progesterone receptors in reporter assays using Huh7 cells (IC50s = >10,000, >10,000, and 1,880 nM, respectively). PF-03882845 (40 and 100...
| Keywords: | 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3S,3aR,4,5-tetrahydro-2H-benz[g]indazole-7-carboxylic acid |
| Application: | Non-steroidal mineralocorticoid receptor antagonist |
| CAS | 1023650-66-9 |
| MW: | 419.9 D |
From 42.00€
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