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DL-Cysteine
Item number: Cay41968-1
A racemic mixture of D- and L-cysteine, prevents reserpine- and pyloric stenosis-induced gastric ulceration in rats at 5% w/v, improves motility and DNA integrity in frozen and thawed epididymal spermatozoa from cats in cryoprotectants at 5 mM. Formulation: A solid. InChI:...
| Keywords: | (±)-Cysteine, (R,S)-Cysteine, NSC 63864 |
| Application: | D-/L-cysteine racemic mixture |
| CAS | 3374-22-9 |
| MW: | 121.16 D |
From 40.00€
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Fmoc-beta-Alanine
Item number: Cay41969-10
A building block, has been used in the solid-phase synthesis of glucagon receptor peptide antagonists and bradykinin B1 and B2 receptor pseudopeptide antagonists. Formulation: A solid. InChI: InChI=1S/C18H17NO4/c20-17(21)9-10-19-18(22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,22)(H,20,21)....
| Keywords: | Fmoc-beta-Ala-OH, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-beta-alanine |
| Application: | Building block |
| CAS | 35737-10-1 |
| MW: | 311.33 D |
From 40.00€
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Coumarin 343
Item number: Cay41970-100
A coumarin laser dye, abs/em = 446/519 nm. Formulation: A solid. InChI: InChI=1S/C16H15NO4/c18-15(19)12-8-10-7-9-3-1-5-17-6-2-4-11(13(9)17)14(10)21-16(12)20/h7-8H,1-6H2,(H,18,19). InChIKey: KCDCNGXPPGQERR-UHFFFAOYSA-N. SMILES: O=C(C1=CC2=C(OC1=O)C(CCCN3CCC4)=C3C4=C2)O
| Keywords: | 2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid |
| Application: | Coumarin laser dye |
| CAS | 55804-65-4 |
| MW: | 285.29 D |
From 55.00€
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ARV-766
Item number: Cay41985-1
A PROTAC that drives androgen receptor degradation (DC50 = <1 nM), inhibits tumor growth in various LNCaP and VCaP prostate cancer mouse xenograft models, including an enzalutamide-insensitive, non-castrated VCaP model. Formulation: A solid. InChI:...
| Keywords: | Luxdegalutamide,... |
| Application: | Androgen receptor degradation driving PROTAC |
| CAS | 2750830-09-0 |
| MW: | 807.95 D |
From 119.00€
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Paltusotine
Item number: Cay42041-10
An SST2 agonist, selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively), reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg, reduces plasma levels of IGF-1 in beagle...
| Keywords: | CRN00808, 3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-benzonitrile |
| Application: | SST2 agonist |
| CAS | 2172870-89-0 |
| MW: | 456.5 D |
From 421.00€
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BI-87G3
Item number: Cay42045-1
A JNK1 inhibitor (IC50 = 1.804 µM), selective for JNK1 over p38alpha MAPK, Akt, furin, and lethal factor (IC50s = >100, >100, >100, and >50 µM, respectively), inhibits TNF-alpha-induced JNK1 phosphorylation in HeLa cells (IC50 = ~15 µM). Formulation: A solid. InChI:...
| Keywords: | c-Jun N-terminal Kinase Inhibitor XI, JNK Inhibitor XI, 2-[(5-nitro-2-thiazolyl)thio]-benzothiazole |
| Application: | JNK1 inhibitor |
| CAS | 2207-44-5 |
| MW: | 295.4 D |
From 40.00€
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KEA1-97
Item number: Cay42049-10
An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in...
| Keywords: | 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine |
| Application: | Trx-caspase-3 protein-protein interaction inhibitor |
| CAS | 2138882-71-8 |
| MW: | 335.16 D |
From 70.00€
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CFT-7455
Item number: Cay42053-1
A cereblon ligand 1-containing degrader of IKZF1 and IKZF3, reduces levels of IKZF1 and IKZF3 in NCI H929 cells at 0.1 nM, decreases the growth of NCI H929 cells (GI50 = 0.0743 nM), reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model at 30 or 100 µg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Cemsidomide, 3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione |
| Application: | Cereblon ligand 1-containing IKZF1 / IKZF3 degrader |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
From 110.00€
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AZ 13705339
Item number: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Keywords: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Application: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
From 116.00€
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GAPDH Inhibitor Compound F8
Item number: Cay42090-1
A covalent inhibitor of GAPDH (IC50 = 39.31 µM), decreases viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. Formulation: A solid. InChI: InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2. InChIKey:...
| Keywords: | 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole |
| Application: | GAPDH covalent inhibitor |
| CAS | 252212-58-1 |
| MW: | 366.37 D |
From 55.00€
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Martinostat
Item number: Cay42100-10
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)....
| Keywords: | N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide |
| Application: | HDAC inhibitor |
| CAS | 1629052-58-9 |
| MW: | 354.5 D |
From 153.00€
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GSK467
Item number: Cay42103-1
A JARID1B inhibitor (IC50 = 0.02-0.1 µM), selective for JARID1B over KMD2, -3, -4, and -5 (IC50s = 1-10 µM). Formulation: A solid. InChI: InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23). InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N. SMILES:...
| Keywords: | 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]- pyrido[3,4-d]pyrimidin-4(3H)-one |
| Application: | JARID1B (KDM5B) inhibitor |
| CAS | 1628332-52-4 |
| MW: | 319.3 D |
From 60.00€
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