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Deferitazole
Item number: Cay33329-1
An iron chelator, decreases the levels of iron in iron-citrate complexes at 50 µM, reduces the number of P. falciparum oocytes, an effect that can be prevented by the addition of ferric chloride, and the percent of flagellated P. falciparum male gametocytes in vitro at 25 µM, decreases the urine and fecal levels of...
| Keywords: | FBS0701, SPD-602, 4S,5-dihydro-2-[2-hydroxy-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid |
| Application: | Iron chelator |
| CAS | 945635-15-4 |
| MW: | 399.46 D |
From 122.00€
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EN4
Item number: Cay33473-10
A covalent inhibitor of c-Myc, inhibits c-Myc-induced increases in transcriptional activity in a reporter assay using HEK293T cells (EC50 = 12.5 µM), reduces the proliferation of 231MFP cells at 50 µM, decreases tumor volume in a 231MFP mouse xenograft model at 50 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-benzamide |
| Application: | Covalent c-Myc inhibitor |
| CAS | 1197824-15-9 |
| MW: | 416.47 D |
From 101.00€
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Erinacine B
Item number: Cay40078-250
A cyathin diterpenoid, induces NGF secretion in isolated mouse astroglial cells at 1 mM. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | (-)-Erinacine B, Erinacin B,... |
| Application: | Cyathin diterpenoid, fungal metabolite |
| CAS | 156101-10-9 |
| MW: | 432.6 D |
535.00€
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Perfluorohexyloctane
Item number: Cay40490-1
A semifluorinated alkane and PFAS, improves corneal penetration of cyclosporine A in porcine eyes ex vivo at 0.05 and 0.1%, topical application improves the lipid layer grade in rabbit eyes in vivo without inducing irritation. Formulation: A solid. InChI:...
| Keywords: | 1-(Perfluorohexyl)octane, F6H8, NOV03, 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-tetradecane |
| Application: | Semifluorinated alkane, PFAS |
| CAS | 133331-77-8 |
| MW: | 432.26 D |
376.00€
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BSJ-04-132
Item number: Cay41248-1
A PROTAC that drives Cdk4 degradation, selectively induces the degradation of Cdk4 over Cdk6, IKZF1, and IKZF3 in a cereblon-dependent manner in Jurkat cells at 1 µM. Formulation: A solid. InChI:...
| Keywords: | 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]... |
| Application: | Cdk4 degradation driving PROTAC |
| CAS | 2349356392 |
| MW: | 819.9 D |
From 178.00€
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E17241
Item number: Cay41675-1
An inducer of ABCA1 expression, induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM), an agonist of PPARs, induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARgamma, PPARalpha, or PPARdelta (EC50s = 290, 3,900, and 879 nM, respectively),...
| Keywords: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| Application: | ABCA1 expression inducer |
| CAS | 1060968-92-4 |
| MW: | 318.4 D |
From 70.00€
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Werner Syndrome RecQ Helicase-IN-2
Item number: Cay41678-1
An inhibitor of WRN (IC50 = 100 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 100 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 120 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Werner Syndrome RecQ Helicase Inhibitor 2, WS RecQ Helicase Inhibitor 2, WS RecQ Helicase-IN-2,... |
| Application: | WRN inhibitor |
| CAS | 2869954-51-6 |
| MW: | 681.7 D |
From 153.00€
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DC-U4106
Item number: Cay41723-1
A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI:...
| Keywords: | 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one |
| Application: | USP8 inhibitor |
| CAS | 2410534-62-0 |
| MW: | 525.6 D |
From 223.00€
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Spongosine
Item number: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Keywords: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Application: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
From 76.00€
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MMV390048
Item number: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Keywords: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Application: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
From 107.00€
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AQW-051
Item number: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Keywords: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Application: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
From 104.00€
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DBCO acid
Item number: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Keywords: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Application: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
From 43.00€
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