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GS-9901
Item number: Cay42105-1
A PI3Kdelta inhibitor (IC50 = 1 nM), selective for PI3Kdelta over PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = 750, 100, and 190 nM, respectively) and a panel of 456 additional kinases, including 11 lipid and 56 mutant kinases, at 10 µM, activates basophils in isolated human whole blood (EC50 = 1 nM), decreases ankle...
| Keywords: | 2,4-diamino-6-[[(S)-[5-chloro-8-fluoro-3,4-dihydro-4-oxo-3-(3-pyridinyl)-2-quinazolinyl]cyclopropylmethyl]amino]-5-pyrimid... |
| Application: | PI3Kdelta inhibitor |
| CAS | 1640247-87-5 |
| MW: | 477.9 D |
From 122.00€
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Pyrotinib (maleate)
Item number: Cay42108-1
An EGFR and HER2 inhibitor (IC50s = 13 and 38 nM, respectively), selectively inhibits the proliferation of HER2+ BT474 and SKOV3 cells (IC50s = 5.1 and 43 nM, respectively) over HER2- MDA-MB-231 cells (IC50 = 3,500 nM), decreases tumor growth without affecting body weight in BT474 and SKOV3 mouse xenograft models at...
| Keywords: | SHR-1258,... |
| Application: | EGFR / HER2 inhibitor |
| CAS | 1397922-61-0 |
| MW: | 815.2 D |
From 214.00€
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2-Amino-9H-pyrido[2,3-b]indole
Item number: Cay42114-10
A mutagenic heterocyclic amine, has been found in cooked foods, mutagenic to S. typhimurium in the Ames test and induces SCEs in NL3 cells, induces hepatic and blood vessel tumor formation in mice at 0.08% in the diet, has been found in the urine of cigarette smokers. Formulation: A solid. InChI:...
| Keywords: | 2-Amino-alpha-Carboline, AalphaC, 9H-pyrido[2,3-b]indol-2-amine |
| Application: | Mutagenic heterocyclic amine |
| CAS | 26148-68-5 |
| MW: | 183.2 D |
From 122.00€
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Dendrophenol
Item number: Cay42115-1
A polyphenol with diverse biological activities, decreases viability of, and induces cell cycle arrest at the S phase in, HCT116 cells at 10 µM, inhibits the migration of MDA-MB-231 cells at 3 or 10 µM, inhibits LPS-induced increases in iNOS, COX-2, HIF-1alpha, and NF-kappaB levels and NF-kappaB nuclear...
| Keywords: | Aloifol II, Moscatilin, 4-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxy-phenol |
| Application: | Bioactive polyphenol |
| CAS | 108853-14-1 |
| MW: | 304.3 D |
From 101.00€
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Phepropeptin C
Item number: Cay10008110-1
A cyclic peptide with proteasome inhibition activity, inhibits isolated mouse liver proteasomes (IC50 = 12.5 µg/ml). Formulation: A powder. InChI:...
| Keywords: | Cyclic(Leu-D-Leu-xi-Ile-Leu-D-Phe-D-Pro), cyclo(L-isoleucyl-L-leucyl-D-phenylalanyl-L-prolyl-L-leucyl-D-leucyl) |
| Application: | Cyclic peptide, proteasome inhibition agent |
| CAS | 396729-25-2 |
| MW: | 696.92 D |
1,068.00€
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BM 567
Item number: Cay10155-1
A dual acting antithrombogenic agent, inhibitor of TXA2 synthase (IC50 = 12 nM), acts as an TP receptor antagonist (IC50 = 1.1 nM). Formulation: A crystalline solid. InChI:...
| Keywords: | 2-(cyclohexylamino)-5-nitro-N-[(pentylamino)carbonyl]-benzenesulfonamide |
| Application: | Dual thromboxane synthase inhibitor, TP receptor antagonist |
| CAS | 284464-77-3 |
| MW: | 412.5 D |
From 95.00€
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PDGFR TKI III
Item number: Cay14925-1
A PDGFRalpha and PDGFRbeta inhibitor (IC50s = 0.05 and 0.13 µM, respectively), selective for PDGFRalpha and PDGFRbeta over FGFR, EGFR, PKA, and PKC (IC50s = 29.7, >30, >30, and >30 µM, respectively) but does inhibit c-Kit and FLT3 (IC50s = 0.05 and 0.23 µM, respectively), inhibits PDGF homodimer-induced...
| Keywords: | PDGFR Tyrosine Kinase Inhibitor III, Platelet-derived Growth Factor Receptor TKI III, Platelet-derived Growth Factor... |
| Application: | PDGFRalpha / PDGFRbeta inhibitor |
| CAS | 205254-94-0 |
| MW: | 485.5 D |
From 55.00€
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GSK180
Item number: Cay19217-1
An inhibitor of kynurenine 3-monooxygenase (IC50 = 6.3 nM), selective for human over P. fluorescens kynurenine 3-monooxygenase (IC50 = 500 nM), increases circulating levels of kynurenine and kynurenic acid in mice at 27 mg/kg, protects against secondary acute lung injury and renal injury in a rat model of...
| Keywords: | 5,6-dichloro-2-oxo-3(2H)-benzoxazolepropanoic acid |
| Application: | Kynurenine 3-monooxygenase inhibitor |
| CAS | 1799725-26-0 |
| MW: | 276.1 D |
From 55.00€
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WAY-181187
Item number: Cay23461-10
A 5-HT6 receptor agonist, increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM), selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively), selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM, increases extracellular...
| Keywords: | SAX 187, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine |
| Application: | 5-HT6 receptor agonist |
| CAS | 554403-49-5 |
| MW: | 380.87 D |
From 105.00€
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Navoximod
Item number: Cay28440-1
An IDO1 inhibitor (IC50 = 28 nM for the recombinant human enzyme), decreases tumor volume in a Panc02 murine PDAC model at 500 mg/kg. Formulation: A solid. InChI: InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11-,12-,15-,17+/m0/s1....
| Keywords: | GDC-0919, NLG-919, RG6078, (aR,5S)-6-fluoro-a-(trans-4-hydroxycyclohexyl)-5H-imidazo[5,1-a]isoindole-5-ethanol |
| Application: | IDO1 inhibitor |
| CAS | 1402837-78-8 |
| MW: | 316.4 D |
From 239.00€
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TC 13172
Item number: Cay31034-1
An inhibitor of MLKL and necroptosis, selective for MLKL over RIPK1 and RIPK3 at 10 µM, inhibits TSZ-induced necroptosis in HT-29 cells (EC50 = 2 nM), inhibits TSZ-induced oligomerization of MLKL and translocation of MLKL to the plasma membrane in HT-29 cells at 100 nM. Formulation: A solid. InChI:...
| Keywords: | 3,7-dihydro-3-[3-(3-hydroxyphenyl)-2-propyn-1-yl]-1,7-dimethyl-8-(methylsulfonyl)-1H-purine-2,6-dione |
| Application: | MLKL / necroptosis inhibitor |
| CAS | 2093393-05-4 |
| MW: | 388.4 D |
From 76.00€
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GLPG1205
Item number: Cay33185-1
A GPR84 antagonist, inhibits DIM-induced GTPgammaS binding in cells overexpressing human GPR84 (IC50 = 54 nM), inhibits embelin-induced chemotaxis of isolated human neutrophils (IC50 = 11 nM), reduces body weight loss and rectal bleeding and improves stool consistency in a rat model of DSS-induced colitis....
| Keywords: | 9-(2-cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one |
| Application: | GPR84 antagonist |
| CAS | 1445847-37-9 |
| MW: | 378.4 D |
From 101.00€
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