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WYneN
Item number: Cay42010-10
A chemoselective probe for protein sulfenylation, selective for sulfenylated proteins over DNTB and 4-DPS, binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection. Formulation: A solid. InChI:...
| Keywords: | Wittig-alkyne N, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-phosphonium, monobromide |
| Application: | Chemoselective protein sulfenylation probe |
| CAS | 3052492-38-0 |
| MW: | 438.3 D |
From 153.00€
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Metapramine
Item number: Cay42033-1
An antidepressant, decreases action potential amplitude and maximal signal velocity and increases conduction time in isolated dog Purkinje fibers at 10 µM, reduces ethanol consumption in ethanol-preferring rats at 10 mg/kg, inhibits reperfusion-induced increases in ventricular arrhythmias in a rat model of...
| Keywords: | RP 19560, 10,11-dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine |
| Application: | Antidepressant |
| CAS | 21730-16-5 |
| MW: | 238.3 D |
From 40.00€
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MitoBloCK-10
Item number: Cay42054-1
A mitochondrial protein import inhibitor, inhibits the import of cytochrome c1 into the mitochondrial intermembrane space in yeast cells at 100 µM, inhibits migration and invasion of, and induces apoptosis and cell cycle arrest at the G1 phase in, primary human bladder cancer cells at 25 µM, induces mitochondrial...
| Keywords: | MB-10, 3-fluoro-benzoic acid 2-[(5-nitro-2-thienyl)methylene]hydrazide |
| Application: | Mitochondrial protein import inhibitor |
| CAS | 394694-98-5 |
| MW: | 293.27 D |
From 40.00€
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MCUF-651
Item number: Cay42055-10
A GC-A positive allosteric modulator, induces the production of cGMP in the presence (EC50 = 0.45 µM) but not the absence of ANP in HEK293 cells expressing human GC-A, selective for GC-A over GC-B in HEK293 cells expressing the human receptors at 10 µM, binds to the GC-A extracellular domain (Kd = 397 nM) and...
| Keywords: | N-(4,6-difluoro-2-benzothiazolyl)-1-[2-(dimethylamino)ethyl]-3-piperidinecarboxamide |
| Application: | GC-A positive allosteric modulator |
| CAS | 2747162-85-0 |
| MW: | 368.45 D |
From 193.00€
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SB-505124 (hydrochloride)
Item number: Cay42056-1
An ALK5 and ALK4 inhibitor (IC50s = 47 and 129 nM, respectively), selective for ALK5 and ALK4 over a panel of 27 kinases at 10 µM, inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 µM, inhibits TGF-beta-induced but not TNF-alpha-induced apoptosis in Fao cells at 1...
| Keywords: | TGF-beta Receptor Type I Kinase Inhibitor III, TGF-beta RI Kinase Inhibitor III,... |
| Application: | ALK5 / ALK4 inhibitor |
| CAS | 356559-13-2 |
| MW: | 371.9 D |
From 40.00€
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PVP-037
Item number: Cay42073-1
A TLR7/8 agonist adjuvant, induces the production of other cytokines and chemokines, including TNF, IFN-gamma, IL-1ß, and IL-6, in primary human PBMCs at =1 µM, increases anti-rHA IgG titers in mice when used as an adjuvant to rHA. Formulation: A solid. InChI:...
| Keywords: | a-ethyl-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methylphenyl)-benzeneacetamide |
| Application: | TLR7/8 agonist adjuvant |
| CAS | 862810-50-2 |
| MW: | 370.5 D |
From 91.00€
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PSB-KK1445
Item number: Cay42093-10
A GPR18 agonist, selective for GPR18 over GPR55 in beta-arrestin recruitment assays using CHO-K1 cells expressing the human receptors (EC50s = 0.0454 and >10 µM, respectively), does not bind to CB1 or CB2 receptors (Kis = >10 µM for both). Formulation: A solid. InChI:...
| Keywords: | 7-[(4-fluorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-1H-purine-2,6-dione |
| Application: | GPR18 agonist |
| CAS | 885896-54-8 |
| MW: | 446.5 D |
From 72.00€
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Ps-Tac
Item number: Cay42357-1
A quenched fluorescent probe for GSTP1 activity, can be used in live cells, selective for GSTP1 over 18 GST subtypes in MCF-7 cells expressing the recombinant human enzymes, upon glutathionylation by GSTP1, nitrite is released, and the fluorescence of the unquenched glutathionylated fluorescein derivative can be...
| Application: | Quenched fluorescent GSTP1 activity probe |
803.00€
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VPS34-IN-19
Item number: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Keywords: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Application: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
From 147.00€
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Dovitinib (lactate)
Item number: Cay41394-1
A multi-kinase inhibitor, inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRalpha, and PDGFRbeta (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively), inhibits the proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500...
| Keywords: | CHIR258, TKI-258, 2-hydroxy-propanoic acid, compd. with... |
| Application: | Multi-kinase inhibitor |
| CAS | 852433-84-2 |
| MW: | 572.59 D |
From 45.00€
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ML-401
Item number: Cay41450-10
An EBI2 antagonist (IC50 = 1.03 nM), inhibits RS11846 cell chemotaxis (IC50 = 4.533 nM). Formulation: A solid. InChI: InChI=1S/C20H20BrClN2O/c21-18-6-1-16(2-7-18)5-10-20(25)24-13-11-23(12-14-24)15-17-3-8-19(22)9-4-17/h1-10H,11-15H2/b10-5+. InChIKey: NXTNVQJKGHAGAX-BJMVGYQFSA-N. SMILES:...
| Keywords: | (2E)-3-(4-bromophenyl)-1-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-propen-1-one |
| Application: | EBI2 antagonist |
| CAS | 1597489-14-9 |
| MW: | 419.74 D |
From 116.00€
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Isoleucine
Item number: Cay41562-50
A mixture of isoleucine diastereomers. Formulation: A solid. InChI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9). InChIKey: AGPKZVBTJJNPAG-UHFFFAOYSA-N. SMILES: CCC(C)C(N)C(O)=O
| Keywords: | 2-amino-3-methyl-pentanoic acid |
| Application: | Isoleucine diastereomer mixture |
| CAS | 2095501-92-9 |
| MW: | 131.2 D |
55.00€
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