9-Methoxyellipticine

Description: 9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V, IC50s = 0.8 and 0.6 µM, respectively). Target: Others. Smiles: COc1ccc2[nH]c3c(C)c4ccncc4c(C)c3c2c1. References: Svoboda, G.H., Poore, G.A., and Montfort, M.L.Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). Isolation of the alkaloids and study of the antitumor properties of 9-methoxyellipticineJ. Pharm. Sci.57(10)1720-1725(1968)