9-Methoxyellipticine

9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine (hydrochloride) (Cay-18742) that has been found in O. maculata and has anticancer activity. It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V, IC50s = 0.8 and 0.6 µM, respectively). 9-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V (IC50s = 0.5 and 0.3 µM, respectively). It also increases survival in a variety of rodent tumor models.Formal Name: 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole. CAS Number: 10371-86-5. Synonyms: Methoxy-9-ellipticine, NSC 69187. Molecular Formula: C18H16N2O. Formula Weight: 276.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 245, 276, 293 nm. SMILES: COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1. InChi Code: InChI=1S/C18H16N2O/c1-10-15-9-19-7-6-13(15)11(2)18-17(10)14-8-12(21-3)4-5-16(14)20-18/h4-9,20H,1-3H3. InChi Key: BKRMCDAOAQWNTG-UHFFFAOYSA-N. Origin: Animal/Bleekeria sp..