9-Deazaguanine

9-Deazaguanine is an analog of guanine that acts as an inhibitor of purine nucleoside phosphorylase (PNP, Kd = 160 nM). Inhibitors of PNP are used to control T cell proliferation, particularly in T cell cancers, autoimmune diseases, and tissue transplant rejection.Formal Name: 2-amino-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one. CAS Number: 65996-58-9. Synonyms: NSC 344522. Molecular Formula: C6H6N4O. Formula Weight: 150.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): slightly soluble. lambdamax: 229, 260 nm. SMILES: NC(N1)=NC2=C(NC=C2)C1=O. InChi Code: InChI=1S/C6H6N4O/c7-6-9-3-1-2-8-4(3)5(11)10-6/h1-2,8H,(H3,7,9,10,11). InChi Key: FFYPRJYSJODFFD-UHFFFAOYSA-N.