8-DY547-cGMP

Through activation by the binding of cyclic nucleotides, cyclic nucleotide-gated (CNG) ion channels mediate sensory signal transduction in photoreceptors and olfactory cells. 8-DY547-cGMP is a fluorescently-labeled cyclic nucleotide that can be used to study CNGA2 channel activation. 8-DY547-cGMP and cGMP open the channel with equal efficiency and control of the channel activity is rapid and reversible. The difference in fluorescence (DeltaF) can be determined by using DY647.Formal Name: 1-ethyl-2-((4E)-4-(1-ethyl-3-(4-(2-(methylthio)ethylamino)-4-oxobutyl)-5-sulfonatoindolin-2-ylidene)but-2-en-2-yl)-3,3-dimethyl-3H-indolium-5-sulfonate-guanosine-3',5'-cyclic monophosphate, disodium salt. Molecular Formula: C42H55N8O14PS3 . 2Na. Formula Weight: 1069.1. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: CC[N+](C(C=C(S(=O)([O-])=O)C=C1)=C1C2(C)C)=C2/C=C/C=C3C(CCCC(NCCSC4NC(C(NC(N)=N5)=O)C5N4C6OC(COP(O7)([O-])=O)C7C6O)=O)(C)C(C=C(S(=O)([O-])=O)C=C8)C8N/3CC.[Na+].[Na+]. InChi Code: InChI=1S/C42H57N8O14PS3.2Na/c1-6-48-27-16-14-23(67(56,57)58)20-26(27)42(5,31(48)11-8-10-30-41(3,4)25-15-13-24(68(59,60)61)21-28(25)49(30)7-2)17-9-12-32(51)44-18-19-66-40-45-33-36(46-39(43)47-37(33)53)50(40)38-34(52)35-29(63-38)22-62-65(54,55)64-35,,/. InChi Key: VKTWASDKFOZMCE-UHFFFAOYSA-L.