7,8-Dihydroneopterin

7,8-Dihydroneopterin is a pteridine with antioxidant activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay when used at concentrations ranging from 20 to 100 µM. 7,8-Dihydroneopterin (2-10 µM) inhibits copper ion-induced oxidation of LDL in a cell-free assay and decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL. It inhibits necrosis induced by oxidized LDL (oxLDL) in U937, but not THP-1, cells when used at a concentration of 200 µM. InChI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1, InChIKey: YQIFAMYNGGOTFB-XINAWCOVSA-N, SMILES: O=C1C2=C(NCC([C@H](O)[C@H](O)CO)=N2)NC(N)=N1