6-OAU

GPR84 is a Galphai protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-alpha production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated alpha protein) when delivered intravenously.Formal Name: 6-(octylamino)-2,4(1H,3H)-pyrimidinedione. CAS Number: 83797-69-7. Molecular Formula: C12H21N3O2. Formula Weight: 239.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 0.25 mg/ml. lambdamax: 265 nm. SMILES: O=C1NC(NCCCCCCCC)=CC(N1)=O. InChi Code: InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17). InChi Key: PFSWASUQURIOOR-UHFFFAOYSA-N.