6-Methoxypurine-9-beta-D-5'(R)-C-methylriboside

Description: 6-Methoxypurine-9-beta-D-5'(R)-C-methylriboside, an analog of hypoxanthine-a purine base predominantly found in muscle tissue and a metabolite generated when purine oxidase acts on xanthine-displays anti-inflammatory properties and functions as a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. Its cytoprotective role is underscored by its ability to inhibit PARP activity, thus preventing peroxynitrite-induced mitochondrial depolarization and subsequent superoxide production. Furthermore, hypoxanthine serves as a biomarker for hypoxia [1] [2]. Target: Others