5'-Thymidylic Acid (sodium salt)

5'-Thymidylic acid (dTMP) is a deoxyribonucleotide. It is formed via methylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis. Oral administration of dTMP in combination with dCMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.CAS Number: 33430-62-5. Synonyms: Deoxythymidine-5'-monophosphate, Thymidine monophosphate, Thymidine-5'-monophosphate, dTMP. Molecular Formula: C10H13N2O8P . 2Na. Formula Weight: 366.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): slightly soluble. lambdamax: 268 nm. SMILES: O=C(N1)C(C)=CN([C@@]2([H])C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C1=O.[Na+].[Na+]. InChi Code: InChI=1S/C10H15N2O8P.2Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18,,/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18),,/q,2*+1/p-2/t6-,7+,8+,,/m0../s1. InChi Key: AGSQMPPRYZYDFV-ZJWYQBPBSA-L.