5'-pGpG (sodium salt)

5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).{24607, 50984, 28201} It is a metabolite of cyclic di-GMP (Cay-17144) formed via hydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP. 5'-pGpG is intended for use as a negative control for cyclic di-GMP signaling.Formal Name: 5'-O-phosphonoguanylyl-(3'->5')-guanosine, trisodium salt. Synonyms: c-di-GMP Control, Cyclic di-GMP Negative Control. Molecular Formula: C20H23N10O15P2 . 3Na. Formula Weight: 774.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: O=P(O[C@H]1[C@@H](O)[C@@](N2C(NC(N)=NC3=O)=C3N=C2)([H])O[C@@H]1COP([O-])([O-])=O)([O-])OC[C@@H]4[C@@H](O)[C@@H](O)[C@@](N5C(NC(N)=NC6=O)=C6N=C5)([H])O4.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C20H26N10O15P2.3Na/c21-19-25-13-7(15(34)27-19)23-3-29(13)17-10(32)9(31)5(43-17)1-42-47(39,40)45-12-6(2-41-46(36,37)38)44-18(11(12)33)30-4-24-8-14(30)26-20(22)28-16(8)35,,,/h3-6,9-12,17-18,31-33H,1-2H2,(H,39,40)(H2,36,37,38)(H3,21,25,27,34)(H3,22,26,28,35),,,/q,3*+1/p-3/t5-,6-,9-,10-,11-,12-,17-,18-,,,/m1.../s1. InChi Key: XZFRJGQKNIQDDO-QQWDMWIMSA-K.