5-Chlorouracil

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil (Cay-26088). In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed. 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.Formal Name: 5-chloro-2,4(1H,3H)-pyrimidinedione. CAS Number: 1820-81-1. Molecular Formula: C4H3ClN2O2. Formula Weight: 146.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 8 mg/ml, DMSO: 0.8 mg/ml, Ethanol: 53 mg/ml, PBS (pH 7.2): 60 mg/ml. lambdamax: 210, 272 nm. SMILES: O=C1NC(NC=C1Cl)=O. InChi Code: InChI=1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9). InChi Key: ZFTBZKVVGZNMJR-UHFFFAOYSA-N.