5,7-Dichlorokynurenic Acid

5,7-Dichlorokyneurenic acid (5,7-DCKA) is a derivative of kynurenic acid (Cay-16792) and an NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay). It selectively inhibits glycine- over kainate-induced NMDA currents at 15 µM in Xenopus oocytes expressing rat NMDA receptors. 5,7-DCKA reduces NMDA-induced neurotoxicity in primary rat cortical neurons by 55 to 90% when used at concentrations ranging from 1 to 10 µM. In vivo, 5,7-DCKA (0.97-97 nmol) reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner. It blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the paraventricular nucleus (PVN) in anesthetized rabbits. 5,7-DCKA also increases social interaction time in the social interaction test and time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, as well as disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm.Formal Name: 5,7-dichloro-4-hydroxy-2-quinolinecarboxylic acid. CAS Number: 131123-76-7. Synonyms: 5,7-DCKA, DCKA. Molecular Formula: C10H5Cl2NO3. Formula Weight: 258.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 228, 256, 342 nm. SMILES: ClC(C=C1Cl)=CC2=C1C(O)=CC(C(O)=O)=N2. InChi Code: InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16). InChi Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N.