4BP-TQS

4BP-TQS is an allosteric agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs). It activates human alpha7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Cay-23829, EC50s = 17 and 128 µM, respectively). It is selective for alpha7 subunit-containing nAChRs, having no activity for alpha1beta1deltaepsilon-, alpha3beta4-, and alpha4beta2 subunit-containing nAChRs at 100 µM. 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of alpha7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes. It activates wild-type alpha7 subunit-containing nAChRs and nAChRs containing the alpha7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.Formal Name: 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide. CAS Number: 360791-49-7. Molecular Formula: C18H17BrN2O2S. Formula Weight: 405.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, Ethanol: 30mg/mL, PBS (pH 7.2): 10mg/mL. lambdamax: 275 nm. SMILES: NS(C1=CC2=C(C=C1)NC(C3=CC=C(Br)C=C3)C4C2C=CC4)(=O)=O. InChi Code: InChI=1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23). InChi Key: YNCXHXYZTLIZTO-UHFFFAOYSA-N.