4A7C-301-Nurr1 Agonist

4A7C-301-Nurr1 agonist is an agonist of nuclear receptor-related 1 (Nurr1). It binds to the Nurr1 ligand-binding domain (LBD, IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively). 4A7C-301-Nurr1 agonist (5 mg/kg per day) decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in mouse models of Parkinson's disease induced by the neurotoxin MPTP or by overexpression of alpha-synuclein.Formal Name: N1-(4,6-bis(4-ethylpiperazin-1-yl)pyrimidin-2-yl)-N2-(7-chloroquinolin-4-yl)ethane-1,2-diamine. Synonyms: 4A7C-301-Nuclear Receptor-Related 1. Molecular Formula: C27H38ClN9. Formula Weight: 524.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml. lambdamax: 221 nm. SMILES: CCN1CCN(C2=CC(N3CCN(CC)CC3)=NC(NCCNC4=C(C=CC(Cl)=C5)C5=NC=C4)=N2)CC1. InChi Code: InChI=1S/C27H38ClN9/c1-3-34-11-15-36(16-12-34)25-20-26(37-17-13-35(4-2)14-18-37)33-27(32-25)31-10-9-30-23-7-8-29-24-19-21(28)5-6-22(23)24/h5-8,19-20H,3-4,9-18H2,1-2H3,(H,29,30)(H,31,32,33). InChi Key: WLTYONMUIIBIKQ-UHFFFAOYSA-N.