4-Methylumbelliferyl 2-sulfamino-2-deoxy-alpha-D-Glucopyranoside (sodium salt)

4-Methylumbelliferyl 2-sulfamino-2-deoxy-alpha-D-Glucopyranoside (4-MU-alpha-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-alpha-GlcNS to yield 4-MU-alpha-GlcNH2, which is then cleaved by alpha-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-alpha-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.Formal Name: 7-[[2-deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one, monosodium salt. CAS Number: 460085-45-4. Synonyms: 4-MU-alpha-GlcNS. Molecular Formula: C16H18NO10S . Na. Formula Weight: 439.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Water: Slightly Soluble. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O1.[Na+]. InChi Code: InChI=1S/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16,/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24),/q,+1/p-1/t11-,13-,14-,15-,16+,/m1./s1. InChi Key: LMECUNAMBHBGFU-MYDYNYEJSA-M.