4-Methylhistamine (hydrochloride)

4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM). It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-beta-galactosidase activity induced by forskolin (Cay-11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It induces a change in eosinophil shape (EC50 = 0.36 µM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 µM), activities that can be inhibited by the histamine H4 antagonist JNJ-7777120 (Cay-10011925). Intratracheal administration of 4-methylhistamine (10 µg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma. 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Cay-14956).Formal Name: 4-methyl-1H-imidazole-5-ethanamine, dihydrochloride. CAS Number: 36376-47-3. Molecular Formula: C6H11N3 . 2HCl. Formula Weight: 198.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: NCCC1=C(C)NC=N1.Cl.Cl. InChi Code: InChI=1S/C6H11N3.2ClH/c1-5-6(2-3-7)9-4-8-5,,/h4H,2-3,7H2,1H3,(H,8,9),2*1H. InChi Key: BVJIXYJOFWYOBL-UHFFFAOYSA-N.