3BrB-PP1

3BrB-PP1 is a bumped kinase inhibitor (BKI) that acts as a selective, ATP-competitive inhibitor of kinases with gatekeeper mutations. It increases the activity of the T. gondii bradyzoite-specific BAG1 promoter. 3BrB-PP1 has been used to study kinase activity using kinases containing mutations at gatekeeper residues in the ATP-binding pocket, thereby allowing 3BrB-PP1 to selectively inhibit the kinase.. SMILES: CC(C)(N1C2=C(C(N)=NC=N2)C(CC3=CC(Br)=CC=C3)=N1)C. InChi Code: InChI=1S/C16H18BrN5/c1-16(2,3)22-15-13(14(18)19-9-20-15)12(21-22)8-10-5-4-6-11(17)7-10/h4-7,9H,8H2,1-3H3,(H2,18,19,20). InChi Key: FTICVONBLRGQJW-UHFFFAOYSA-N