33-BCRP Inhibitor

33-BCRP inhibitor is an inhibitor of breast cancer resistance protein (BCRP). It sensitizes mitoxantrone-resistant H460/MX20 lung cancer cells to mitoxantrone-induced cell death alone and in combination with UV radiation. 33-BCRP inhibitor also sensitizes KB-C2 epidermal carcinoma cells overexpressing P-glycoprotein (P-gp), also known as multidrug resistance protein (MDR), to colchicine-induced cell death. It increases intracellular accumulation of mitoxantrone (Cay-14842) in H460/MX20 cells when used at a concentration of 5 µM.Formal Name: N-(4-azidophenyl)-2-(pyridin-4-yl)quinazolin-4-amine. Synonyms: 33-Breast Cancer Resistance Protein Inhibitor. Molecular Formula: C19H13N7. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 249 nm. SMILES: [N-]=[N+]=NC(C=C1)=CC=C1NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42. InChi Code: InChI=1S/C19H13N7/c20-26-25-15-7-5-14(6-8-15)22-19-16-3-1-2-4-17(16)23-18(24-19)13-9-11-21-12-10-13/h1-12H,(H,22,23,24). InChi Key: RKCAPAXYHIXQLP-UHFFFAOYSA-N.