3-O-methyl Quercetin

3-O-methyl Quercetin is a flavone that has been found in C. balchaschensis and has diverse biological activities. It is an inhibitor of beta-secretase (IC50 = 6.5 µM). It scavenges DPPH (Cay-14805) radicals and superoxide anions in cell-free assays (IC50s = 14.17 and 17.39 µM, respectively), as well as inhibits lipid peroxidation and hydrogen peroxide-induced neuronal cell death in primary rat cortical cells (IC50s = 19 and 3.5 µM, respectively). 3-O-methyl Quercetin inhibits poliovirus RNA synthesis in infected HeLa cells when used at concentrations of 2 and 20 µg/ml. It also inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 3.8 µM) and reduces LPS-induced increases in the levels of inducible nitric oxide synthase (iNOS) in BV-2 microglia.Formal Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-4H-1-benzopyran-4-one. CAS Number: 1486-70-0. Synonyms: NSC 154016, Quercetin 3-methyl ether. Molecular Formula: C16H12O7. Formula Weight: 316.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble. SMILES: OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(OC)C2=O)=C1. InChi Code: InChI=1S/C16H12O7/c1-22-16-14(21)13-11(20)5-8(17)6-12(13)23-15(16)7-2-3-9(18)10(19)4-7/h2-6,17-20H,1H3. InChi Key: WEPBGSIAWZTEJR-UHFFFAOYSA-N. Origin: Synthetic.